Chest
Effects of Nifedipine on Ventilation/Perfusion Matching in Primary Pulmonary Hypertension
Section snippets
CASE 1
A 61-year-old woman was admitted with a history of progressively severe exertional dyspnea and fatigue over the preceding ten years. She denied previous use of drugs and had never before had symptoms suggestive of cardiac or pulmonary disease. From three years before admission, exertional dyspnea had become invalidating (walking on level ground) and was accompanied by chest pain and palpitations and on four occasions by syncope. One year before admission, a right heart catheterization showed
DISCUSSION
Dantzker and Bower2 have recently shown by the multiple inert gas elimination technique that / relationships in patients with chronic obliterative pulmonary vascular disease (idiopathic or secondary to recurrent pulmonary emboli) are only minimally abnormal, with a mean of 10 percent of cardiac output perfusing units with low / . The same authors demonstrated that in such patients reduction of pulmonary vascular tone by an infusion of nitroprusside or
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Manuscript received May 10; revision accepted August 23.