Chest
Original ResearchDiffuse Lung DiseaseTelomere Length in Interstitial Lung Diseases
Section snippets
Results
Relative TL was determined in control subjects and patients diagnosed with the following ILDs: sarcoidosis, HP, CTD-ILD, iNSIP, SR-ILD, COP, IPF, and FIP (Table 1).
Discussion
This study shows that telomeres of patients with ILD are shorter compared with those of healthy control subjects. However, the degree of difference in TL differs significantly between the different ILD diagnoses and particularly within the IIP subgroup. Within familial disease, TL correlates with the underlying genetic cause. This is a large study on TL and ILD, including eight different ILD diagnoses and 532 subjects, and is the first study, to our knowledge, to separately analyze different
Acknowledgments
Author contributions: R. S., C. H. M. v. M., and J. C. G. had full access to all of the data in the study, and take responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. R. S. served as principal author. R. S., C. H. M. v. M., K. M. K., J. J. v. d. V., and J. C. G. contributed to the study concept and design; K. M. K. and J. J. v. d. V. contributed to data collection; R. S., C. H. M. v. M., K. M. K., J. J. v. d. V., P.
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FUNDING/SUPPORT: Funding for this study was received from the St. Antonius Research Fund and the Pender Foundation.
Part of this study was presented at the International World Association for Sarcoidosis and Other Granulomatous Disorders (WASOG) Conference on Diffuse Parenchymal Lung Diseases, June 6-7, 2013, Paris, France, and the Pittsburgh-Munich International Lung Conference, October 23-24, 2014, Pittsburgh, PA.
originally published Online First May 14, 2015.