Chest
Original Research: SARCOIDOSISPrevalence of Hypothyroidism and Graves Disease in Sarcoidosis
Section snippets
S Patients
A total of 111 S patients who had been consecutively referred to the Respiratory Pathophysiology Section of the University of Pisa were recruited into the study. S was diagnosed according to the accepted criteria123; only patients with biopsy-proven cases of S have been included. Thyroid evaluation was performed before the start of corticosteroid treatment in S patients.
Control Group-General Population
Each of the S patients who was eligible for the study was matched, by sex and age, one to three with a control group of
Results in Female S Patients and Female Control Subjects
TSH serum and AbTPO levels were significantly higher in S patients than in the group of female control subjects (Table 2). Subclinical hypothyroidism (defined as a TSH level of > 3.6 μU/mL with FT4 and FT3 levels within the normal range) was significantly more common in S than in control subjects, as was clinical hypothyroidism (defined as a TSH level of > 3.6 μU/mL with FT4 levels below the normal range). The mean TSH level was 4.5 ± 2.8 μU/mL (range, 3.7 to 11.7 μU/mL) in S patients with
DISCUSSION
Discrepant results have been reported about the prevalence of different antithyroid autoantibodies and hypothyroidism.5678910 The results of our study, using more tests and more sensitive methodology, in a larger group of 111 S patients who were matched by gender18 and age with 333 control subjects, who had a similar risk for iodine deficiency, demonstrated a significantly higher prevalence (5% and 17%, respectively) for clinical and subclinical hypothyroidism in female S patients than in
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