Chest
Original ResearchA Comparison of Health-Related Quality of Life in Idiopathic Pulmonary Fibrosis and Chronic Hypersensitivity Pneumonitis
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Study Design and Patient Population
Patients with IPF and CHP were identified from an ongoing longitudinal cohort of patients with ILD seen at the University of California, San Francisco from January 2010 to August 2012. During this time period, only 2% of patients who were eligible for inclusion into the ILD cohort chose to decline. Informed consent was obtained on all patients. The University of California San Francisco Committee on Human Research approved the protocol (10-01592).
Patients with IPF or CHP who had completed an
Patient Characteristics and Clinical Symptoms
We analyzed a total of 171 patients with ILD. Of these, 102 had IPF, and 69 had CHP. Patients with IPF were older, more likely to be men, and more likely to be ever smokers (Table 1). Patients with CHP were more likely to be taking prednisone at the time of HRQL assessment. Lung function, as measured by FVC % predicted and diffusing capacity of the lung for carbon monoxide (Dlco) % predicted, was similar between both groups.
Patients with CHP more commonly reported pain than patients with IPF
Discussion
This study demonstrates that level of HRQL impairment, as assessed by PCS and MCS scores, is different between two subtypes of ILD, IPF and CHP, and is independent of age and pulmonary disease severity. Key covariates partly explaining the association between ILD subtype and PCS are dyspnea and fatigue; key covariates between ILD subtype and MCS are dyspnea, female sex, and fatigue.
We hypothesize that the worse quality of life seen in CHP is largely due to these key covariates and not
Acknowledgments
Author contributions: Dr Lee takes responsibility for the content of the manuscript, including the data and analysis.
Dr Lubin: contributed to conception and design; data acquisition, analysis, and interpretation; revision of the manuscript for important intellectual content; and final approval of the version to be published.
Dr Chen: contributed to analysis and interpretation of the data, revision of the manuscript for important intellectual content, and final approval of the version to be
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Funding/Support: This publication was supported by the National Center for Advancing Translational Science, National Institutes of Health [UCSF-CTI KL2TR000143].
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