Chest
Original Research: Sleep DisordersEffect of CPAP on Blood Pressure in Patients With OSA/Hypopnea: A Systematic Review and Meta-analysis
Section snippets
Materials and Methods
An extended version of the Materials and Methods section is presented in e-Appendix 1. The systematic review and meta-analysis adhere to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement for reporting on systematic reviews.14 We conducted the meta-analysis in accordance with the general guidelines of the Cochrane Handbook for Systematic Reviews of Interventions.14, 15
Study Selection
From a total of 1,599 reports in the initial search, we identified 31 studies11, 12, 13, 16, 17, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 that met the inclusion criteria and included these in the systematic review, with 29 being included in the main meta-analysis (n = 1,820) (Fig 1).12, 13, 16, 17, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 42, 43, 44, 45, 46, 47, 48, 49 The κ statistic indicated a strong
Discussion
The results of the present meta-analysis indicate that CPAP is associated with a significant reduction in both systolic and diastolic BP with respect to passive treatment with a low to moderate effect size. Because most of the included primary studies showed either a low or very-low quality, these results should be regarded with caution. However, when analyzing only the intermediate-to high-quality studies, the results are strengthened, and there is a tendency toward a more marked BP lowering
Acknowledgments
Author contributions: Dr Fava had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Fava: contributed to the study design, literature search, data extraction, statistical analysis, and drafting of the manuscript.
Dr Dorigoni: contributed to the study design, retrieval of studies, data extraction from the original articles, statistical analysis, and drafting of the manuscript.
Dr Dalle Vedove: contributed to
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Drs Dorigoni and Dalle Vedove contributed equally to this work.
Funding/Support: The authors have reported to CHEST that no funding was received for this study.
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