Chest
Clinical Investigations: COPDLow-Grade Systemic Inflammation and the Response to Exercise Training in Patients With Advanced COPD
Section snippets
Patients
Seventy-eight consecutive patients with COPD who attended the respiratory outpatient clinic between May 2002 and October 2003 with complaints of dyspnea and poor exercise performance volunteered to participate (Table 1). Patients had no cardiovascular, renal, or neurologic disorders, and did not experience an acute COPD exacerbation in the 3-month period before baseline testing. The Medical Ethical Board of the University Hospitals Leuven approved this open prospective intervention study. All
Baseline
Table 1 shows the baseline characteristics of the patients who completed the exercise-training program (n = 65) and of those who did not complete it (eg, no 12-week assessment). Patients who dropped out due to various reasons (Fig 1 of the online data supplement) had similar baseline characteristics as those who completed the protocol.
Patients who completed the program generally had moderate-to-severe airway obstruction, normal body mass index, and a moderately reduced arterial oxygen tension(
DISCUSSION
Previously, studies have shown that the response to exercise training in patients with COPD was independent of baseline age,24 baseline FEV1,25 and baseline arterial blood gas levels.26 On the contrary, worse baseline physical fitness and muscle weakness, and somewhat worse ventilatory reserve could partially explain the relative response to a 12-week exercise-training program.5, 27 This, however, appears to be common sense.
This is the first clinical study to investigate whether and to what
CONCLUSIONS
In the present study, baseline low-grade systemic inflammation did not explain many of the effects following a 12-week exercise-training program in patients with COPD, except for sTNFR-p55 in the female patients.
ACKNOWLEDGMENTS
The authors are grateful to physiotherapists V. Barbier, I. Coosemans, and A. Cattaert, and to chest physicians P. Bogaerts and A.J.T. Debrock for testing all of the subjects and for their professional guidance of the exercise-training sessions; and to physiotherapist A. Van Severen for gathering all the data. Furthermore, they are indebted to all participants who graciously consented to participate.
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This study was supported by Fonds voor Wetenschappelijk Onderzoek (FWO) Vlaanderen, Levenslijn grant 7.0007.00. Dr. Spruit is a postdoctoral fellow at the Katholieke Universiteit Leuven (PDM/04/230). Dr. Troosters is a postdoctoral fellow of the FWO Vlaanderen.