Chest
Clinical InvestigationMassive Hemoptysis in Cystic Fibrosis
Section snippets
Materials and Methods
The CFF supports and accredits CF care centers nationwide. These centers provide specialized care for persons with CF and offer comprehensive diagnosis and treatment, as well as participation in clinical trials of experimental therapies. The CFF Patient Registry contains data on patients with CF seen at one of the accredited CF care centers in the United States. This represents approximately 90% of all CF patients in the United States. The CFF has sponsored the patient registry since 1966 and
Results
There were 1,153 patients (4.1% of the total population) who had at least one episode of massive hemoptysis. Sixteen of these patients did not have a date recorded for their single episode of massive hemoptysis and are not included in all analyses. There were a total of 1,606 entries with massive hemoptysis as a complication; 15 of these entries did not have dates and are not included in some analyses. Most patients had only one recorded event (n = 858), although many had more than one reported
Discussion
Hemoptysis is common for patients with CF, although typically the bleeding is scant or mild. Massive hemoptysis occurs frequently in patients with CF as well. In this analysis of 10 years of data, collected from a large population of patients with CF, we found that 4.1% of patients overall had at least one episode of massive hemoptysis. In addition, there is a high risk of subsequent episodes of massive hemoptysis. Nearly 26% of patients had more than one occurrence. The database only takes
Acknowledgments
The authors are grateful to Dr. Preston Campbell and Dr. Bruce Marshall for editorial assistance.
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This work was supported in part by a grant from the Cystic Fibrosis Foundation.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml)