Chest
Clinical Investigations in Critical CareNew Formula for Predicting Mean Pulmonary Artery Pressure Using Systolic Pulmonary Artery Pressure
Section snippets
Patients
The prospective study was approved by the ethics board of Paris-Sud 11 University, and informed consent was obtained for all patients. The study involved 31 patients (23 men and 8 women) who had been referred to our catheterization laboratory either for severe PH or for the investigation of chest pain, heart failure, or other cardiovascular disorders. PH was defined by an MPAP of > 25 mm Hg at rest while the patient was breathing room air. Precapillary (ie, arterial) and postcapillary (ie,
Results
In the overall population (31 patients), there was a positive linear relationship between MPAP and SPAP (r2 = 0.982), DPAP (r2 = 0.958), and pulmonary artery pulse pressure (r2 = 0.900). Individual pressure values are given in Table 2. When SPAP was considered as the independent variable in the test sample, MPAP and SPAP were linearly related according to the following equation: MPAP = 0.61 SPAP + 2 mm Hg (r2 = 0.979; 16 patients) [Fig 1].
When the MPAP formula that was obtained in the test
Discussion
The present prospective study demonstrates that MPAP can be accurately predicted from SPAP according to the following formula:
In their pioneer study, Laskey et al9 provided individual high-fidelity pressure values in 10 normotensive subjects and 8 PPH patients (see Tables 1 and 2 in Laskey et al9). The MPAP vs SPAP relationship that we have calculated from their data9 is as follows: MPAP = 0.61 SPAP + 1 mm Hg (r2 = 0.99; MPAP range, 9 to 67 mm Hg). The equation calculated
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