Chest
Clinical InvestigationsCOPDAcute Effects of Hyperoxia on Dyspnea in Hypoxemia Patients With Chronic Airway Obstruction at Rest
Section snippets
Patients
The study was performed on 10 male patients with severe CAO receiving long-term oxygen. Nine patients had COPD, and one patient had bronchiectasis (Table 1). Diagnosis was made according to American Thoracic Society (ATS) guidelines.13 One patient with COPD (patient 7) had chronic pleural effusion. The patients were clinically and functionally stable at the time of the study, ie, absence of exacerbation and significant changes in spirometry during the preceding 4 weeks. No patients received
Results
All patients had severe obstructive pulmonary disease characterized by FEV1 < 42% predicted and FEV1/FVC < 54% (Table 1). In patient 5, who had bronchiectasis, the TLC was below the normal limits, a common feature in this disease, though the increased body weight (body mass index of 31) probably also contributed to his restrictive pattern. Only one patient (patient 10) was a responder to bronchodilation (ΔFEV1 = 21% of control) according to ATS but not European Respiratory Society criteria.
Discussion
The results of this study indicate that in patients with CAO receiving long-term domiciliary oxygen for severe hypoxemia, hyperoxic breathing at rest induces a significant reduction of ventilation and DH with concurrent improvement of dyspnea sensation.
References (30)
- et al.
Oxygen relieves breathlessness in “pink puffers.”
Lancet
(1981) Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease
Ann Intern Med
(1980)- et al.
Early effects of oxygen administration and prognosis in chronic obstructive pulmonary disease and cor pulmonale
Am Rev Respir Dis
(1983) - et al.
Relationship between ventilation and breathlessness during exercise in chronic obstructive airways disease is not altered by prevention of hypoxaemia
Clin Sci
(1984) - et al.
Supplemental oxygen and exercise ability in chronic obstructive airways disease
Thorax
(1988) - et al.
The effect of nasal flow on breathlessness in patients with chronic obstructive pulmonary disease
Am Rev Respir Dis
(1988) - et al.
Symptomatic benefit of supplemental oxygen in hypoxemic patients with chronic lung disease
Am Rev Respir Dis
(1991) Intrinsic PEEP
- et al.
Force reserve of the diaphragm in patients with chronic obstructive pulmonary disease
J Appl Physiol
(1983) - et al.
Relationship between chronic dyspnea and expiratory flow limitation in COPD patients
Am J Respir Crit Care Med
(1996)
Occlusion pressure as a measure of respiratory center output in conscious man
Respir Physiol
Effect of salbutamol on dynamic hyperinflation in chronic obstructive pulmonary disease patients
Eur Respir J
Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma
Am Rev Respir Dis
Lung function testing: selection of reference values and interpretative strategies
Am Rev Respir Dis
Multiple breath helium dilution measurement of lung volumes in adults
Eur Respir J
Cited by (0)
This work was performed at Service de Réanimation Médicale et Assistance Respiratoire, Hôpital de la Croix-Rousse, Lyon, France.