Chest
Occupational and Environmental Lung DiseaseRisk of Asthma Among Finnish Patients With Occupational Rhinitis
Section snippets
Study Population
The study population consisted of nonasthmatic patients entered into the Finnish Register of Occupational Diseases because of an occupational disease in from 1988 to 1999. Those reported to have occupational rhinitis (n = 3,637) were compared with those reported to have an occupational disease other than occupational rhinitis, asthma, allergic alveolitis, or allergic contact dermatitis (n = 31,457). The term reference population is hereafter used to for the latter group. The reference
Results
Of the 3,637 patients with occupational rhinitis, 420 (11.6%) received diagnoses of asthma during the follow-up period compared with 972 diagnoses of asthma (3.1%) among the 31,457 persons in the reference population. The crude incidence rate of asthma was 19 per 1,000 population per year for those with occupational rhinitis and 4.0 per 1,000 population per year for the reference population. When only those persons with occupational rhinitis that had been accepted by the insurance system were
Discussion
We found a clearly elevated risk of asthma among patients with occupational rhinitis compared with patients with other occupational diseases. Unfortunately, we did not have systematic information on exposure circumstances after the occupational rhinitis had been reported. For those who later contracted occupational asthma (ie, 37% of all those patients with asthma), the comparison of job titles at the time of notification of occupational rhinitis and the notification of occupational asthma
ACKNOWLEDGMENT
We are indebted to Kari Toivola and Timo Pitkonen of the Finnish Social Insurance Institution, and to Ilpo Mäkinen and Anja Saalo of the Finnish Register of Occupational Diseases for their assistance in building the data files. We thank Ms. Georgianna Oja for the linguistic revision of the manuscript.
References (13)
- et al.
Perennial rhinitis: an independent risk factor for asthma in nonatopic subjects
J Allergy Clin Immunol
(1999) - et al.
Occupational asthma
Lancet
(1997) - et al.
How much adult asthma can be attributed to occupational factors?
Am J Med
(1999) - et al.
Allergic rhinitis and its impact on asthma
J Allergy Clin Immunol
(2001) - et al.
The risk of occupational rhinitis
Int Arch Occup Environ Health
(1997) - et al.
Upper airways involvement
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Work-Related Upper-Airway Disorders
2020, Clinics in Chest MedicineCitation Excerpt :The temporal relationship between the two was not adequately addressed in the literature with only 4 of the 15 explicitly examining temporality. From these, 20% to 56% of patients had nasal symptoms or a diagnosis of OR before diagnosis with occupational asthma.12–15 In 2 studies,9,13 the association of OR with occupational asthma was higher in those individuals exposed to HMW sensitizers when compared with LMW agents, although this has not been consistently reported in the literature.16
Occupational Rhinitis
2020, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Epidemiological studies have identified risk factors for the development of OA that could be considered for a more personalized management approach to minimize the socioeconomic impact of the disease. The female sex41,42 and a familial history of allergy or asthma42 have been associated with a 3 times higher risk of subsequent OA. However, atopy (especially polysensitization to common allergens), severe OR symptoms, and the presence of asymptomatic nonspecific bronchial hyperresponsiveness may also be associated with an increased risk of OA because these characteristics were important cofactors in determining the risk of developing asthma among individuals with nonoccupational rhinitis45,106-108 In these patients, complete removal from exposure should be more strongly recommended.
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The study was financially supported by a grant from the Ministry of Social Affairs and Health, Department for Promotion of Welfare and Health.