Chest
Clinical InvestigationsIncreased 8-Isoprostane and Interleukin-6 in Breath Condensate of Obstructive Sleep Apnea Patients
Section snippets
Patients
The study population consisted of 18 OSA patients, 10 subjects matched for obesity who did not have OSA, and 15 age-matched normal control subjects (Table 1). All subjects were white and were recruited from the sleep laboratory of the Respiratory Disease Institute at University of Bari (Italy). Written informed consent was obtained from all subjects, and the institutional ethics committee approved the study. A complete physical examination was performed, including neurologic, cardiopulmonary,
IL-6
IL-6 was measurable in the breath condensate of all subjects. Concentrations were significantly greater in obese patients (2.1 ŷ 0.2 pg/mL; p < 0.05) and in OSA patients (8.7 ŷ 0.3 pg/mL; p < 0.0001) than in healthy subjects (1.6 ŷ 0.1 pg/mL) [Fig 1, left, A]. There was a significant difference between OSA and obese patients (p < 0.0001). A positive correlation was found between IL-6 and AHI levels (r = 0.6; p < 0.0005) [Fig 2, left, A] and IL-6 and neck circumference (r = 0.5; p < 0.01) [Fig 2
Discussion
This study shows that IL-6 and 8-isoprostane are detectable in breath condensates and that their concentrations are higher in OSA patients, are intermediate in obese subjects without sleep apnea, and are lower in healthy subjects. A relationship between the two markers and the severity of OSA also was found. The positive correlation between neck circumference and the concentrations of the two markers may be useful to screen obese subjects who are at high risk for developing sleep apnea.
Our
ACKNOWLEDGMENT
We gratefully acknowledge the assistance of Dr. F. Carpagnano, without whose dedicated and expert technical assistance this study would not have been possible.
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