Chest
Original ResearchAsthmaCharacteristics of Perimenstrual Asthma and Its Relation to Asthma Severity and Control: Data From the Severe Asthma Research Program
Section snippets
Population and Subject Characterization
Subjects were part of SARP, the details of which have been previously described.10 Severe asthma was defined by the 2000 American Thoracic Society workshop criteria, with a combination of one of two major and two of seven minor criteria.12 All other subjects with asthma enrolled in SARP were termed “not severe” as detailed by Moore et al.10 All subjects completed questionnaires on a range of topics. Pulmonary function testing was performed according to American Thoracic Society guidelines as
Baseline Characteristics
Of the 756 female subjects enrolled into SARP, those aged < 12 years (n = 47) and > 50 years (n = 146) were excluded from analysis. In the remaining 563, 14% (n = 80) did not know whether menses exacerbated their asthma and were eliminated from further analysis, suggesting that most subjects could answer the question. Ultimately, 483 subjects were included in this analysis. Women unable to answer the PMA question (e-Tables 1, 2) generally had a more severe condition but did not differ in other
Discussion
It is increasingly clear that hormonal influences affect asthma phenotypes and severity. Although asthma is more common in boys, at the time of puberty and beyond, it becomes more common in girls and women.14 The subset of women with PMA remains poorly characterized. Definitions have differed across studies, and no large-scale analyses have been performed.15, 16 To this end, > 500 women with a range of asthma severity recruited for SARP were analyzed for PMA. The data from this largest study to
Acknowledgments
Author contributions: All the authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Rao: contributed to the data analysis and preparation and critical review of the manuscript.
Dr Moore: contributed to the data analysis and preparation and critical review of the manuscript.
Dr Bleecker: contributed to the study design, recruitment of participants, data acquisition, and preparation and critical review
References (35)
Relation of perimenstrual asthma with disease severity and other allergic co-morbidities—the first report of perimenstrual asthma prevalence in Saudi Arabia
Allergol Immunopathol (Madr)
(2011)- et al.
Perimenstrual asthma: a syndrome without known cause or cure
J Allergy Clin Immunol
(2003) - et al.
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
J Allergy Clin Immunol
(2007) - et al.
Morbidity in asthma in relation to the menstrual cycle
J Allergy Clin Immunol
(1986) - et al.
Premenstrual asthma and atopy markers
Ann Allergy Asthma Immunol
(2010) Asthma variation with menstruation
Br J Dis Chest
(1981)- et al.
Changes in exhaled nitric oxide related to estrogen and progesterone during the menstrual cycle
Chest
(2009) - et al.
Near-fatal asthma related to menstruation
J Allergy Clin Immunol
(2004) - et al.
Is pre-menstrual asthma related to use of aspirin or non-steroidal anti-inflammatory drugs?
Respir Med
(2000) - et al.
A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis
Chest
(2009)
Sex dependence of airflow limitation and air trapping in children with severe asthma
J Allergy Clin Immunol
Factors influencing asthma remission: a longitudinal study from childhood to middle age
Thorax
Risk factors and characteristics associated with severe and difficult to treat asthma phenotype: an analysis of the ENFUMOSA group of patients based on the ECRHS questionnaire
Clin Exp Allergy
Near-fatal asthma phenotype in the ENFUMOSA cohort
Clin Exp Allergy
A different disease, many diseases or mild asthma gone bad? Challenges of severe asthma
Eur Respir J
Relation between phase of the menstrual cycle and asthma presentations in the emergency department
Thorax
The role of female sex hormones in the development and severity of allergic and non-allergic asthma
Clin Exp Allergy
Cited by (83)
Asthma and Rhinitis Through the Lifespan of Nonpregnant Women
2023, Journal of Allergy and Clinical Immunology: In PracticeProgestogen Hypersensitivity
2023, Journal of Allergy and Clinical Immunology: In PracticeAiming to Improve Equity in Lung Health: Sex and Gender
2023, Clinics in Chest MedicinePerimenstrual Asthma and Premenstrual Disorders in Adolescents with Asthma
2023, Journal of Pediatric and Adolescent GynecologyAllergy to airborne allergens and menstrual cycles of women treated for infertility
2022, Revue Francaise d'AllergologieCitation Excerpt :Block of eNOS (genetic or pharmacologial) alleviated any differences in anaphylactic reaction. Moreover, there is a term of perimenstrual asthma (PMA) mentioned in the scientific literature, associated with cyclic loss of asthma control on initial days of menstruation [12]. In this article we present results of our study on atopy and allergic disorders in women treated for infertility of various aetiology.
Funding/Support: This work was supported by the National Institutes of Health [Grants HL69116, HL69130, HL69155, HL69167, HL69170, HL69174, HL69349, HL091762, KL2RR025009, M01 RR02635, M01 RR03186, M01 RR007122-14, 1UL1RR024153, 1UL1RR024989, 1UL1RR024992, 1UL1RR025008, and 1UL1RR025011].
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.