Chest
Clinical Investigations: Sexual PulmonaryRegulation of Breathing and Perception of Dyspnea in Healthy Pregnant Women
Section snippets
Subjects
Thirty-five healthy pregnant women without history of cardiovascular or respiratory diseases were recruited for the protocol. All women had uncomplicated singleton pregnancies. Each woman was studied serially at weeks 12, 24, and 36 of gestation and again 4 months postpartum for a measurement in the nonpregnant state. Twelve of the subjects failed to complete all trials (for reasons unrelated to the study), and their data were not included in the analysis. Twenty-three women completed the
RESULTS
Eleven of the 23 subjects had dyspnea at rest and comprise the dyspneic group. Dyspnea started within the first trimester and it disappeared after delivery. In four subjects, the dyspnea remained at a constant level, although this condition partially improved as the pregnancy progressed in seven women. Nevertheless, none of the dyspneic women with Borg scores greater than 0 at 12 weeks subsequently became nondyspneic at 24 and 36 weeks. The mean intensity ratings (Borg score) fell between 1 and
DISCUSSION
Our results suggest that the P0.1 and the responses to the hypercapnia and hypoxia are higher in pregnant women with physiologic dyspnea than in those who are asymptomatic, and that these alterations are related to the intensity of dyspnea.
Several methodologic issues should be considered. Pregnancy dyspnea was classified as physiologic only in accordance with clinical aspects. The typical clinical manifestations (dyspnea that does not affect normal activity and that appears to remain stable
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