Chest
Volume 142, Issue 2, August 2012, Pages 543-544
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Correspondence
Ciliary Beat Pattern Analysis Below 37°C May Increase Risk of Primary Ciliary Dyskinesia Misdiagnosis

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To the Editor

We read with interest the article by Smith et al1 published in CHEST (July 2011). The authors analyzed ciliary function in 14 nasal turbinate brushing biopsy specimens that provided ciliated epithelium from healthy human volunteers. The authors stated that ciliary function was maintained at temperatures ranging between 37°C and 2°C, contrary to previous research suggesting that cilia stop beating at 4°C,2, 3, 4 and a sigmoid relationship between ciliary beat frequency (CBF) and temperature was

Acknowledgments

Role of sponsors: The sponsor had no role in the design of the study, the collection and analysis of the data, or in the preparation of the manuscript.

Other contributions: Informed consent was provided by the parents of this case for use of clinical information and samples for academic research for “A study of the pathophysiology and clinical manifestations of PCD and other chronic respiratory disease of childhood” (LREC 06/Q1702/109).

Additional information: The videos can be found in the

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Funding/Support: The National Diagnostic PCD service in Southampton is funded by the National Specialised Commissioning Team.

Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.

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