Chest
CorrespondenceIncreased Number of Pulmonary Embolisms in Sarcoidosis Patients
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To the Editor
We read with great interest the article by Swigris et al1 in a recent issue of CHEST (November 2011), in which the authors found an increased risk of pulmonary embolisms (PEs) among US decedents with sarcoidosis. They found PE in 2.54% of patients' death certificates, which compares with 1.13% of the background population. A recent observation in our own clinic of two patients with sarcoidosis experiencing extensive PEs triggered our interest in a possible underlying association.
We have
References (3)
- et al.
Increased risk of pulmonary embolism among US decedents with sarcoidosis from 1988-2007
Chest
(2011)
Cited by (22)
Venous thromboembolism in sarcoidosis: Mere comorbidity or catalyst for disease evolution?
2024, Respiratory Medicine and ResearchSarcoidosis-Associated Pulmonary Hypertension
2024, Clinics in Chest MedicinePrognostic impact of venous thromboembolism on the course of sarcoidosis: A multicenter retrospective case-control study
2023, Respiratory Medicine and ResearchClinical Phenotypes of Sarcoidosis-Associated Pulmonary Hypertension
2021, Heart Lung and CirculationCitation Excerpt :Other mechanisms have been described, such as specific vasculopathy, left heart disease and extrinsic compression of the pulmonary vasculature [3,9–11]. Patients with sarcoidosis also have a higher prevalence of pulmonary emboli and sleep apnoea [12–15]. These different mechanisms might have implications for the disease, including therapy and prognosis [9].
Adult interstitial lung diseases and their epidemiology
2020, Presse MedicaleCitation Excerpt :Interestingly, a clustering of disease onset between January and May is noted only in HLA-DRB1*03 positive patients, suggesting the responsibility of season-specific antigens [77]. Sarcoidosis is significantly associated with an increased risk of venous thromboembolic events (HR = 2–4) [82–85], congestive heart failure (HR = 1.7–2.7) and cerebrovascular accident (HR = 3.3) [82,86]. It has been suggested that sleep apnea may be more frequent in sarcoidosis than in controls [87].
Severe Sarcoidosis
2015, Clinics in Chest MedicineCitation Excerpt :In pulmonary disease, a low threshold for suspecting supervening pulmonary embolism, fungal infection, or PH is especially important: An increased prevalence of pulmonary embolism, compared with the general population, has been reported in 2 retrospective studies.75,76 Chronic aspergillus infection, which may cause life-threatening hemoptysis, was present in 2% in a large retrospective study,77 but is likely to be much higher in severe fibrotic disease: the 2 predisposing factors are immunosuppressive treatment and the presence of upper lobe fibrobullous distortion.78–81
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