Chest
Clinical Investigations: CardiologyDesquamative Interstitial Pneumonitis and Diffuse Alveolar Damage in Textile Workers: Potential Role of Mycotoxins
Section snippets
Case Series
Five male textile workers, aged 26 to 53 years, presented between April 1990 and November 1991 with breathlessness and cough (Table 1). Two patients had mild constitutional symptoms. The duration of symptoms prior to presentation ranged from 3 months to 5 years. All patients suffered acute exacerbations 5 to 7 days prior to their presentation. Severity of symptoms appeared to relate to duration of symptoms and duration of employment (range, 18 months to 8 years).
On examination, all patients
Discussion
The existence of DIP, as described by Liebow,1,2 as a distinct clinical entity has been debated for many years.3, 4, 5, 6, 7, 8 In most cases, there is no known cause, and DIP is still considered a subtype of idiopathic pulmonary fibrosis. This categorization remains useful clinically in predicting response to therapy and prognosis.3,8,9 More recently, “DIP-like” reactions have been described, which may be diffuse or focal (Table 2).6, 7, 8,10 This term is used when the pathologic features of
Acknowledgments
The writers thank Dr. Meri Bukowskyj, Respirology and Internal Medicine, Kingston, Canada, for generously sharing data with us; Dr. Alan Fletcher, Department of Pathology, Kingston (Canada) General Hospital, for his assistance in the interpretation of the pathologic findings of these cases; and Dr. Lewis Tomalty of the Department of Microbiology, Kingston General Hospital, and Dr. David Miller of the Plant Research Center, Ottawa (Canada) Experimental Farm, for their assistance in performing
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2022, Journal of Hazardous MaterialsCitation Excerpt :A recent review discusses occupational diseases resulting from MP exposure (Prata, 2018). Briefly, there were reports about pneumoconiosis (Ng et al., 1991; Studnicka et al., 1995), interstitial lung disease (Cortez Pimentel et al., 1975; Kern et al., 1998; Eschenbacher et al., 1999), chronic bronchitis (Cortez Pimentel et al., 1975; Miller et al., 1975), and various other acute and chronic symptoms, including cough and dyspnea (Valic and Zuskin, 1977; Zuskin et al., 1998; Lougheed et al., 1995; Kern et al., 2000). Apart from that, occupational exposure to MP has been correlated to allergic and asthmatic reactions (Cortez Pimentel et al., 1975; Muittari and Veneskoski, 1978).
Idiopathic interstitial pneumonias
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2018, ChestCitation Excerpt :Based on data from several studies, 60% to 90% of DIP cases are reported in smokers.30,32,36 However, in contrast to RB-ILD, which is almost exclusively a smoker’s disease, DIP has been reported secondary to other causes such as connective tissue diseases (eg, rheumatoid arthritis [RA], systemic sclerosis),37,38 occupational exposure (eg, mycotoxins, dust, solder fumes, flock-workers),24,39-41 drugs (eg, sirolimus),42 and infections.43 Symptoms of patients with DIP are similar to RB-ILD (Table 1).
Airborne microplastics: Consequences to human health?
2018, Environmental PollutionCitation Excerpt :Consequently, airborne microplastics may exert toxicity in other organs besides the respiratory system. Even though in vivo studies support the role of particles in the pathogenesis of the described occupational diseases (Agarwal et al., 1978; Pimentel et al., 1975; Porter et al., 1999), other agents may be involved (Donaldson and Tran, 2002; Pauly et al., 1998) such as monomers and additives (Eckardt, 1976), processing chemicals (Helal and Elshafy, 2012; Sati et al., 2011; Zuskin et al., 1998), degradation products (Burkhart et al., 1999a, 1999b; Kern et al., 1998; Washko et al., 1998), microorganisms and their toxins (Burkhart et al., 1999a; Lougheed et al., 1995). The importance of particle and chemical toxicity in the pathogenesis is not yet clear.
Imaging of Occupational Lung Disease
2016, Radiologic Clinics of North America
Presented in part at the Royal College of Physicians and Surgeons of Canada Annual Meeting, September 11–14, 1992, Ottowa. Manuscript received August 24, 1994; revision accepted June 9, 1995.