Chest
Clinical InvestigationsBronchogenic Carcinoma in Patients with Pulmonary Histiocytosis X
Section snippets
Patients with Bronchogenic Carcinoma (Table 1)
The mean age of our patients at the time of diagnosis of Hx was 42 years. Histiocytosis X was diagnosed either by open lung biopsy (four cases) or bone biopsy (one case). The chest roentgenogram was always abnormal, showing various associations of reticulation, cysts, and nodules, according to the classification of Basset et al.3 Bronchogenic carcinoma occurred 10.5 years on the average (range, 5 to 20 years) after the discovery of Hx. The type of carcinoma varied: squamous cell (patients 1 and
Discussion
Among the 93 cases of pulmonary Hx diagnosed, we observed the development of lung carcinoma in five patients after a mean Hx duration of 10.5 years. The annual bronchogenic carcinoma risk of 1,040/ 100,000 appears exceptionally high, lending support to the notion that patients with pulmonary Hx have a high risk of developing lung carcinoma. Moreover, since many of our patients were younger than 40 years old at the time of the last consultation, the observed rate of bronchogenic carcinoma
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Cited by (34)
Pulmonary manifestations of Langerhans cell histiocytosis
2015, Revue des Maladies RespiratoiresPulmonary adenocarcinoma in a young patient of pulmonary langerhans cell histiocytosis (PLCH)
2013, Journal of Thoracic OncologyCitation Excerpt :Association between bronchogenic carcinoma and PLCH has been reported in few case series and case reports, but overall it is rare and quite unusual. Sadoun et al.1 reported five bronchogenic carcinoma cases in a series of 93 PLCH patients; Vassallo et al.2 reported five primary lung cancers in a series of 102 cases with PLCH, and Lombard et al.3 reported four lung cancer cases of 130 pulmonary PLCH patients. The hypotheses of increased risk of bronchogenic carcinoma in lung scar tissue caused by fibrosis in PLCH plus the fact that most of PLCH patients are current smokers or have a history of smoking and combination of the both are thought to be the underlying causes of increased incidence of lung carcinoma in PLCH patients.
FDG-PET/CT in pulmonary and cardiac Langerhans' cell histiocytosis and metastatic non-small cell lung cancer
2012, Nuclear Medicine and BiologyAdult pulmonary Langerhans cell histiocytosis
2004, EMC - PneumologiePulmonary Langerhans cell histiocytosis: Emerging concepts in pathobiology, radiology, and clinical evolution of disease
2003, ChestCitation Excerpt :Smoking cessation is recommended because of a potential pathogenetic association,2324 the rarely documented resolution of disease following cessation of smoking52 and the increased risk of bronchogenic cancer in PLCH.65 The nature of cancer in patients with PLCH does not appear to be that of a scar cancer.66 Bronchogenic cancers have been reported most commonly in those who continue to smoke heavily.66
Adult pulmonary Langerhans' cell histiocytosis
2003, Revue de Medecine Interne
Manuscript received October 17, 1990; revision accepted September 16, 1991.