Chest
Survival in COPD Patients with a Daytime PaO2 >60 mm Hg with and without Nocturnal Oxyhemoglobin Desaturation
Section snippets
Patient Selection
This was a multicenter, retrospective study with data contributed from sleep centers focusing on the study of NOD in patients with COPD. The participating centers were asked to provide data for µp to 75 variables on each patient who met the following criteria:
- 1.
A nocturnal polysomnographic sleep recording was. available with calibrated ear or pulse oximetry to measure continuous SaO2 and electroencephalographic leads to verify sleep stages according to standard criteria.11 The patient had
RESULTS
Five centers submitted data on 178 subjects, 169 (161 males, 8 females) of whom met the inclusion criteria, had sufficient sleep data and provided follow-up data on each subject. The longest survival was 7 1/2 years and the shortest was one month. Median follow-up time for the entire group was 3.4 years.
DISCUSSION
This study provides from 6 months to 7 1/2 years of follow-up in 169 COPD patients in whom formal polysomnography with ear or finger plethysmographic sleep SaO2, blood gas values and spirometry were available from the point of inclusion. Thus, we were able to classify patients according to the pattern of nocturnal SaO2 and compare survival. Because of the lack of a standardized definition of NOD, we used two published criteria, one which incorporates criteria for episodic REM-related
REFERENCES (20)
- et al.
Cardiopulmonary hemodynamics during sleep in subjects with chronic obstructive pulmonary disease: the effect of short and long term oxygen
Chest
(1984) - et al.
Nocturnal oxyhemoglobin desaturation in COPD patients with arterial oxygen tensions above 60 mm Hg
Chest
(1987) Clinical hypoxia: causes, consequences, and correction
Lancet
(1978)- et al.
The origins of cor pulmonale, a hypothesis
Chest
(1979) - et al.
Nocturnal pulmonary hypertension in patients with chronic obstructive pulmonary disease
Chest
(1979) - et al.
Oxygen desaturation during sleep as a determinant of the “blue and bloated” syndrome
Chest
(1981) Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease
Ann Intern Med
(1980)Long-term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema
Lancet
(1981)- et al.
Hemodynamic response to oxygen therapy in chronic obstructive pulmonary disease
Ann Intern Med
(1985) - et al.
A double-blind trial of nocturnal supplemental oxygen for sleep desaturation in patients with chronic obstructive pulmonary disease and a daytime PaO2 above 60 torr
Submitted
(1990)
Cited by (0)
This is a cooperative study of the International Oxygen Club. The following are contributing centers: Eugene C. Fletcher, M.D., Associate Professor of Medicine, and Charles C. Miller III, Baylor College of Medicine, Houston, TX. Claudio F. Donner, M.D., Professor of Medicine, and Alberto Braghiroli, M.D., Divisione di Pneumologia, Centro Medico di Riabilitazione, Veruno, Italy. Bengt Midgren, M.D., Lund University Hospital, Lund, Sweden. Pierre Levi-Valensi, M.D., Professor of Medicine, and Ziad Rida, M.D., University of Picardie, C.H.U.— Hopital Sud Amiens, France. Jan Zielinski, M.D., Professor of Medicine, Department of Respiratory Medicine, Institute of Tuberculosis, Warsaw, Poland. Supported in part by the General Research Service of the Department of Veterans Affairs, the Swedish Heart and Lung Foundation (Dr. Midgren) and by individual grants from: DeVilbiss Health Care Inc., Somerset, PA; Healthdyne Technologies, Marietta, GA; Mountain Medical Inc., Denver, CO; and Puritan Bennett Inc., Lenexa, KS.