Chest
Original ResearchObstructive Lung DiseasesTask-Related Oxygen Uptake During Domestic Activities of Daily Life in Patients With COPD and Healthy Elderly Subjects
Section snippets
Materials and Methods
Details on the methods are provided in e-Appendix 1. One hundred patients with COPD and 20 healthy elderly peers volunteered to participate in the study, which was approved by the institutional review board of the Maastricht University Medical Centre (MEC08-3-032). Informed consent was obtained from potential participants, and study eligibility was determined.
Patients were recruited at CIRO+.28 Patients were clinically stable (no exacerbation in the past 4 weeks) and were on various
Characteristics
Patients had moderate to very severe COPD. The proportion of men and the average age were comparable between patients and healthy subjects. Patients had a significantly lower BMI and FFM index compared with healthy subjects. Moreover, patients had higher scores on the (age-adjusted) Charlson Comorbidity Index (e-Table 2, Table 1).31, 32
Patients obtained a significantly lower peak aerobic capacity (mL/min), peak heart rate (beats/min), and peak ventilation (L) than the healthy elderly subjects.
Discussion
The present study shows that patients with COPD use a higher proportion of their peak aerobic capacity and peak ventilation to perform domestic ADLs than healthy elderly subjects, particularly those patients with GOLD stage IV disease, MRC dyspnea grade 5, or BODE score of ≥ 6 points accompanied by higher task-related Borg dyspnea scores. Moreover, patients with COPD have a significantly higher task-related oxygen uptake per kilogram FFM compared with their healthy peers, even those with GOLD
Acknowledgments
Author contributions: Ms Vaes and Dr Spruit had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Ms Vaes: contributed to the acquisition, analysis, and interpretation of the data; drafting the manuscript and revising it for important intellectual content; and approving the final manuscript.
Dr Wouters: contributed to the study concept and design, revising the manuscript for important intellectual content, and
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Funding/Support: This work was funded by Foundation ‘De Weijerhorst.’
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