Chest
Original ResearchCystic FibrosisBone Health, Daily Physical Activity, and Exercise Tolerance in Patients With Cystic Fibrosis
Section snippets
Population and Study Design
The participants were patients of the Specialized Unit of Cystic Fibrosis of the Virgen del Rocío Hospital (Sevilla, Spain). This study was approved by the ethical committee of the hospital, and written informed consent was obtained from all participants. An observational analytic and cross-sectional study was designed. All patients aged ≥ 16 years of age with CF (two positive sweat tests, compatible clinical and confirmation genetic) were invited to participate and included, provided that they
Results
Fifty patients (46% men) were included in the study. Table 1, Table 2 shows the patient characteristics.
Discussion
When monitoring daily PA, it was noted that the most active patients had the greatest bone mass. The results of the cardiopulmonary exercise test and 6-min walk test confirmed these results. However, no association between BMD and vertebral fracture was found. To our knowledge, no previous study has analyzed the level of PA of patients with CF in real time and the possible relationship of PA to BMD.
Previously, other authors compared the level of PA with BMD using questionnaires and observed a
Acknowledgments
Author contributions: Dr Tejero García had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Tejero García: contributed to the conception and design of the study; data acquisition and analysis; interpretation of information; and preparation, revision, review, and approval of the final manuscript.
Dr Giráldez Sánchez: contributed to the conception and design of the study; data analysis; interpretation of the
References (31)
- et al.
Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients
Am J Clin Nutr
(2001) - et al.
Severe osteopenia in CFTR-null mice
Bone
(2004) - et al.
The genetic background of osteoporosis in cystic fibrosis: association analysis with polymorphic markers in four candidate genes
J Cyst Fibros
(2006) - et al.
Weight-bearing exercise and bone mineral accrual in children and adolescents: a review of controlled trials
Bone
(2007) - et al.
Osteoporosis in lung transplantation candidates with end-stage pulmonary disease
Am J Med
(1996) - et al.
Inspiratory muscle training improves lung function and exercise capacity in adults with cystic fibrosis
Chest
(2004) - et al.
A randomized controlled trial of a 3-year home exercise program in cystic fibrosis
J Pediatr
(2000) - et al.
Role of exercise and nutrition status on bone mineral density in cystic fibrosis
J Cyst Fibros
(2003) - et al.
Bone mineral density in cystic fibrosis: benefit of exercise capacity
J Clin Densitom
(2008) - et al.
Exercise during childhood and adolescence: a prophylaxis against cystic fibrosis-related low bone mineral density? Exercise for bone health in children with cystic fibrosis
J Cyst Fibros
(2008)
Evaluation of a portable device to measure daily energy expenditure in free-living adults
Am J Clin Nutr
Vertebral fractures in osteoporosis: a new method for clinical assessment
J Clin Densitom
Prevalence of vertebral fractures in adults with cystic fibrosis and their relationship to bone mineral density
Chest
Adult cystic fibrosis
JAMA
Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors
Thorax
Cited by (51)
Physical activity and exercise training in cystic fibrosis [1]
2022, Paediatric Respiratory ReviewsCitation Excerpt :Regular physical activity slows the rate of decline in pulmonary function by improving sputum clearance [12,13]. It may also positively impact type I diabetes [14], bone mineral density [15], anxiety and depression, and health-related quality of life (HRQoL) [16]. Side effects appear to be rare [17].
Nasal high-flow therapy as an adjunct to exercise in patients with cystic fibrosis: A pilot feasibility trial
2021, Journal of Cystic FibrosisCystic fibrosis bone disease: Pathophysiology, assessment and prognostic implications
2019, Journal of Cystic FibrosisPhysical activity and associations with clinical outcome measures in adults with cystic fibrosis; a systematic review
2019, Journal of Cystic FibrosisCitation Excerpt :Life expectancy of patients with Cystic Fibrosis (CF) continues to increase with improvements in treatments over recent decades, resulting in a greater proportion of adults living with CF [1]. Physical activity (PA) is associated with a number of potential benefits in the management of CF including positive effects on lung function [2], mucociliary clearance [3], bone health [4] and hospitalisation frequency [5]. Higher levels of PA are also associated with improved exercise capacity [6], which is in turn associated with reduced mortality in patients with CF [7].
Exercise and Lung Function in Child Health and Disease
2019, Kendig's Disorders of the Respiratory Tract in ChildrenThe treatment of the pulmonary and extrapulmonary manifestations of cystic fibrosis
2017, Presse Medicale
Funding/Support: This study was developed at the University Hospital Virgen del Rocío de Sevilla, Spain, and supported by a grant (9,000 Euros) from the Association of Pulmonologists of Southern Spain (Neumosur).
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).