Chest
Original ResearchTobacco Cessation & PreventionA Randomized Trial of Parental Behavioral Counseling and Cotinine Feedback for Lowering Environmental Tobacco Smoke Exposure in Children With Asthma: Results of the LET'S Manage Asthma Trial
Section snippets
Materials and Methods
Study methods were approved by the Institutional Review Board of the Kaiser Foundation Research Institute (No. CN-01HFarb-01-H). Additional methods and results information is available in e-Appendix 1.
Results
Recruitment occurred from April 2003 to September 2005. Three hundred eighty-four families met all eligibility criteria for participation, and 352 were randomized (Fig 1). Three hundred thirty-four (94.9%) provided questionnaire data and/or a urine sample at the 6-month follow-up visit, and 336 (95.5%) at the 12-month follow-up visit. Baseline and follow-up data on the use of health-care services and pharmacy dispensing were available for all participants.
Discussion
In the overall sample, the LET'S intervention did not have a statistically or clinically significant effect on any of the primary or secondary outcomes. This is a disappointing outcome, but one that is not unusual in the history of the development of what have subsequently become effective tobacco control interventions.
However, in children who were at high risk for subsequent exacerbations, the intervention was associated with substantially (∼ 90%) and significantly lower secondhand smoke
Conclusions
The study did not demonstrate an effect of the LET'S intervention on secondhand tobacco smoke exposure in the reference population of children with asthma. However, it did provide some evidence, short of conventional statistical proof, of an effect in children whose use of health-care services and overuse of rescue medication would classify them as having high-risk asthma.
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Funding/Support: This research was supported by the National Institutes of Health [Grant NIH RO1 HL70012; Sandra R. Wilson, PhD, principal investigator].
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).