Chest
Original ResearchDiffuse Lung DiseaseSarcoidosis in Black Women in the United States: Data From the Black Women's Health Study
Section snippets
Establishment of the BWHS and Follow-up
The human subjects' protocol for this study was approved by the Boston University Medical Center Institutional Review Board. The BWHS began in 1995 when 59,000 women aged 21 to 69 years enrolled through postal health questionnaires, which were sent to subscribers of Essence magazine, members of selected black women's professional organizations, and friends and relatives of early respondents. Participants indicated their informed consent by completing the questionnaires. At baseline, subjects
Prevalence, Incidence, and Demographics Among BWHS and Sarcoidosis Cases
Among the 59,027 participants in the BWHS, 685 had sarcoidosis at the time they enrolled in the study, for a prevalence of 1,160/100,000 or 1.2%. In addition, 435 incident cases were reported during 611,585 person-years of follow-up from 1995 through 2007, for an average annual incidence rate of 71/100,000. Incidence was highest, 92/100,000, among women in their 40s (Fig 1). The median age at diagnosis was 32 years (range: 16-63 years) for prevalent cases and 44 years (range: 22-77 years) for
Discussion
Our study reports on the largest sample to date of sarcoidosis in black women in the United States. We estimated an annual incidence rate of sarcoidosis of 71/100,000 over a 12-year period based on 435 incident cases, with a peak age-specific rate of 92/100,000 at ages 40 to 49. The current prevalence is 2.0%. Rybicki et al11 observed an average annual incidence rate of 39/100,000 during a 5-year period of observation, and a peak age-specific incidence of 107/100,000 for black women aged 30 to
Acknowledgments
Author contributions: Dr Cozier: contributed to originating the idea for this study, supervising the data collection, designing the physician questionnaire and participant supplemental survey, analyzing and interpreting the data, and writing the article.
Dr Berman: contributed to originating the idea for this study, designing the physician questionnaire and participant supplemental survey, analyzing and interpreting the data, and writing the article.
Dr Palmer: contributed to originating the idea
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Funding/Support: This work was supported by the National Cancer Institute [Grant CA58420]; and National Heart, Lung, and Blood Institute [Grant K01HL088709].
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