Chest
Original ResearchLung TransplantationLung Allocation Score for Lung Transplantation: Impact on Disease Severity and Survival
Section snippets
Data Collection
Using data from the United Network of Organ Sharing (UNOS), we performed analyses on two different data sets available as of May 05, 2007: (1) 170 patients listed between May 4, 2003, and May 3, 2006, at University of Washington Medical Center; and (2) 127 lung transplant recipients who underwent transplantation in the same time period. Each data set was then divided into two cohorts: the pre-LAS cohort included patients who were listed (or underwent transplantation) 2 years prior to LAS
Waiting List Patients
A total of 170 patients (pre-LAS cohort, n = 102; post-LAS cohort, n = 68) were listed for lung transplantation in region 6 between May 4, 2003, and May 3, 2006 (Fig 1). No differences in patient characteristics were observed between LAS cohorts, except for the following: (1) proportionately fewer white patients were listed in the post-LAS cohort in comparison to the pre-LAS cohort (pre-LAS cohort, 94%; vs post-LAS cohort, 84%; p = 0.04); and (2) the patients listed after LAS had a lower mean
Discussion
Our findings suggest that the implementation of the LAS system led to significant differences in the diagnoses for patients who underwent transplantation; however, there was no significant change in diagnoses listed. Few clinically significant changes between pre-LAS and post-LAS cohorts were observed in patient characteristics overall and when stratified by disease in either the transplant-recipient or candidate data set. In addition, we also observed that transplant recipients in the pre-LAS
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This work was performed at the University of Washington, Seattle, WA.
This work was supported by Health Resources and Services Administration contract 234-2005-370011C. The content is the responsibility of the authors alone and does not necessarily reflect views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government.
The authors have no conflicts of interest to disclose.