Chest
Original ResearchORGANIZING PNEUMONIAFocal Organizing Pneumonia on Surgical Lung Biopsy: Causes, Clinicoradiologic Features, and Outcomes
Section snippets
Materials and Methods
Patients with OP diagnosed by surgical lung biopsy at the Mayo Clinic in Rochester, MN, from January 1, 1997, to December 31, 2004, were identified by a computer-assisted search of medical records. There were 203 patients whose surgical lung biopsy specimens demonstrated OP; 26 patients (13%) presented with a unifocal lesion on chest imaging and were included in the study group. This study was approved by the Institutional Review Board of the Mayo Foundation.
Demographics and Clinical Presentation
The median age of the patients was 66 years (range, 36 to 86 years); 11 patients (42%) were women (Table 1). Seven patients were current smokers (27%). No other relevant exposure was elicited except for one patient who worked as a welder. Ten patients (38%) had symptoms, as listed on Table 1; the remaining 16 patients (62%) were asymptomatic. Twenty patients (77%) had no relevant findings on physical examination; the remaining 6 patients were noted to have bibasilar crackles or wheezes, which
Discussion
OP is a nonspecific histopathologic lesion and can be associated with various clinical contexts and radiologic patterns. In this study, we focused on OP presenting as a unifocal lesion on chest imaging (ie, focal OP), which accounted for 13% of cases of OP diagnosed from surgical lung biopsy specimens at our institution over an 8-year period. Other studies61617 have reported similar rates of focal OP among their case series of OP. The majority of our patients with focal OP were asymptomatic,
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Algorithmic Approach to the Diagnosis of Organizing Pneumonia: A Correlation of Clinical, Radiologic, and Pathologic Features
2022, ChestCitation Excerpt :Pulmonary function test results can show mild to moderate restriction with reduction in diffusion capacity; however, obstructive ventilatory defects may be seen in smokers.3,11 These test results may be normal, especially in patients with FOP.22 Diagnosis of OP in some instances requires histopathologic confirmation.
Idiopathic interstitial pneumonias
2019, Difficult to Diagnose Rare Diffuse Lung DiseaseTumors that mimic diffuse parenchymal lung disease
2019, Difficult to Diagnose Rare Diffuse Lung DiseaseThe Role of Infection in Interstitial Lung Diseases: A Review
2017, ChestCitation Excerpt :An organizing pneumonia pattern of lung injury can be seen with many forms of pulmonary infections, including bacterial, viral, fungal, and parasitic.33-35 It seems likely that even some cases diagnosed as cryptogenic organizing pneumonia that have a self-limited clinical course represent resolving pulmonary infection.36 DAD is the histopathologic pattern underlying an acute form of IIP—acute interstitial pneumonia—and most cases of ARDS.4,25,37
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.