Prevention of Catheter-Related Infections Using A Closed Hub System in Patients With Pulmonary Arterial Hypertension

Satoshi Akagi; Hiromi Matsubara; Aiko Ogawa; Yusuke Kawai; Kenichi Hisamatsu; Katsumasa Miyaji; Mitsuru Munemasa; Yoshihisa Fujimoto; Kengo Fukushima Kusano; Tohru Ohe

doi:10.1253/circj.71.559

Clinical Investigation

Prevention of Catheter-Related Infections Using A Closed Hub System in Patients With Pulmonary Arterial Hypertension

Satoshi Akagi, Hiromi Matsubara, Aiko Ogawa, Yusuke Kawai, Kenichi Hisamatsu, Katsumasa Miyaji, Mitsuru Munemasa, Yoshihisa Fujimoto, Kengo Fukushima Kusano, Tohru Ohe

Author information

Satoshi Akagi
Division of Cardiology, National Hospital Organization Okayama Medical Center
Hiromi Matsubara
Division of Cardiology, National Hospital Organization Okayama Medical Center
Aiko Ogawa
Department of Cardiovascular Medicine Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Yusuke Kawai
Division of Cardiology, National Hospital Organization Okayama Medical Center
Kenichi Hisamatsu
Division of Cardiology, National Hospital Organization Okayama Medical Center
Katsumasa Miyaji
Division of Cardiology, National Hospital Organization Okayama Medical Center
Mitsuru Munemasa
Division of Cardiology, National Hospital Organization Okayama Medical Center
Yoshihisa Fujimoto
Division of Cardiology, National Hospital Organization Okayama Medical Center
Kengo Fukushima Kusano
Department of Cardiovascular Medicine Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Tohru Ohe
Department of Cardiovascular Medicine Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

Keywords: Catheter-related bloodstream infection, Catheter-related infection, Closed hub system, Epoprostenol, Pulmonary arterial hypertension

JOURNAL FREE ACCESS

2007 Volume 71 Issue 4 Pages 559-564

DOI https://doi.org/10.1253/circj.71.559

Details

Abstract

Background Most of the patients with pulmonary arterial hypertension (PAH) receiving intravenous epoprostenol have experienced catheter-related infections during long-term treatment. Catheter hub was reported to be the most important source of catheter-related infections. To prevent the catheter-related infections, we have introduced a closed hub system and compared the incidence of catheter-related infections with that in patients using a non-closed hub system. Methods and Results We evaluated the results obtained on 24 occasions in 20 patients with PAH between June 1999 and December 2005. On 11 occasions, a non-closed hub system was used and on 13 cases a closed hub system. We classified the catheter-related infection into a catheter-related bloodstream infection (CRBSI) group or a tunnel infection group based on the pathway of bacteria. The CRBSI rate was 0.89 per 1,000 catheter days in the non-closed hub system group vs 0.10 per 1,000 catheter days in the closed hub system group. Kaplan - Meier analysis showed that the risk of CRBSI significantly decreased in the closed hub system group. None of the patients died as a direct consequence of catheter-related infection during the study period. Conclusions We successfully prevented CRBSI by using a closed hub system. (Circ J 2007; 71: 559 - 564)

Corresponding author

Register with J-STAGE for free!