Original ArticlesSpirometer-triggered high-resolution computed tomography and pulmonary function measurements during an acute exacerbation in patients with cystic fibrosis☆,☆☆,★
Section snippets
Patients
From May 1997 to February 1999, 17 patients (8 males and 9 females) with a diagnosis of CF confirmed by pilocarpine iontophoresis sweat chloride test or CF gene mutation analysis and mild to severe obstructive lung disease (forced expiratory volume in 1 second: 33%-81% predicted) were enrolled in this study. They were prospectively evaluated at Lucile Salter Packard Children’s Hospital at Stanford University by means of standardized spirometer-triggered HRCT of the chest, pulmonary function
Results
The demographic characteristics, treatment, initial PFT values, and Brasfield scores for the 17 subjects are shown (Table I).Patient No. Age (y), Sex Height (cm) Weight (kg) Treatment FVC (% Pred) FEV1 (% Pred) FEF25-75% (% Pred) Brasfield score (2-reader average) 1 13, M 155.6 36.8 OP 57 46 30 17 2 33, F 157.3 44.0 IH 102 78 35 14.5 3 28, M 165.0 50.5 IH 68 49 14 9.5 4 13, M 153.0 37.1 IH 68 59 37 18.5 5 11, F 136.1 28.0 OP 82 78 85 21.5 6 19, M 173.0 70.8 IH 101 95 87 14 7 15, F 162.0 62.0 OP 96 78 44 16 8 13.5, M 167.1 60.3 OP 78 55 21 16.5 9 12, M
Discussion
In this study, patients with CF were evaluated before and after treatment for a pulmonary exacerbation with an HRCT scoring system that incorporated spirometer-triggered inspiratory and expiratory CT imaging. HRCT scans were thus obtained at known lung volumes near TLC for inspiratory scans and near functional residual capacity (8%-21% SVC] and near RV [3%-10% SVC] for expiratory scans. This technique ensured that comparable images were obtained for serial evaluations. Because comparable
Acknowledgements
We thank Glenn Hodge, RPFT, and Colleen Dunn, RPFT, from the pediatric pulmonary function laboratory for their assistance in pulmonary function testing, and Lisa McClennan, RT, and Diane Holmes, RT, from the Pediatric Radiology Section for their assistance with the ultrafast CT imaging.
References (14)
- et al.
Sputum changes associated with therapy for endobronchial exacerbation in cystic fibrosis
J Pediatr
(1988) - et al.
Cystic fibrosis: scoring system with thin-section CT
Radiology
(1991) - et al.
Cystic fibrosis in children: HRCT findings and distribution of disease
J Thorac Imaging
(1996) - et al.
Ultrafast computerized tomography of the chest in cystic fibrosis: a new scoring system
Pediatr Pulmonol
(1991) - et al.
Cystic fibrosis: when should high-resolution computed tomography of the chest be obtained?
Pediatrics
(1998) - et al.
High-resolution CT in the acute exacerbation of cystic fibrosis: evaluation of acute findings, reversibility of those findings, and clinical correlation
AJR Am J Roentgenol
(1997) - et al.
Cystic fibrosis: CT assessment of lung involvement in children and adults
Radiology
(1999)
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Supported by a research grant from Cystic Fibrosis Research, Inc.
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Terry E. Robinson, MD, is a consultant for Imatron, Inc.
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Reprint requests: Terry E. Robinson, MD, Pediatric Pulmonary Division, Stanford University Medical Center, 701 Welch Rd, Whelan Building, No. 3328, Palo Alto, CA 94304-5786.