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Inhibition of phosphodiesterase 11 (PDE11) impacts on sperm quality

International Journal of Impotence Research volume 17, pages 385–386 (2005)Cite this article

Comment on ‘High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11 A4 suggests the absence of PDE11 A4 cross-reaction in patients.’ by Weeks JL, Zoraghi R, Beasley A, Sekhar KR, Francis SH, Corbin JD. (Int J Impot Res 2004 Nov 11 [Epub ahead of print]).

There is a growing interest worldwide in understanding potential crossreaction of PDE5 inhibitors with other proteins and we agree with the authors that PDE11 is one of the obvious candidates, since it is closely related to the PDE5. Weeks et al should be congratulated because, comparing the potencies of tadalafil, vardenafil and sildenafil for PDE11A4 and the fold selectivity of these inhibitors for PDE5A1 over PDE11A4, they provide several important information for safety issues.

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References

  1. Weeks JL et al. High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients. Int J Impot Res 2004 Nov 11 [Epub ahead of print].

  2. Bischoff E . Potency, selectivity, and consequences of nonselectivity of PDE inhibition. Int J Impot Res. 2004; 16(Suppl 1): S11–S14.

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  4. Pomara G et al. Effect of acute in vivo sildenafil or tadalafil treatments on semen parameters in patients with fertility problem, a randomized, double-blind, crossover study. Oral Communication. 7th Congress of the European Society for Sexual Medicine. London, December 2004.

  5. Wayman C et al. Ablation of phosphodiesterase 11 (PDE11) impacts sperm physiology. Oral Communication. 7th Congress of the European Society for Sexual Medicine. London, December 2004.

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Authors and Affiliations

  1. Section of Urology, Department of Surgery, S Chiara Hospital, Pisa University, Italy

    G Pomara & G Morelli

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  1. G Pomara
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  2. G Morelli
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Correspondence to G Pomara.

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Pomara, G., Morelli, G. Inhibition of phosphodiesterase 11 (PDE11) impacts on sperm quality. Int J Impot Res 17, 385–386 (2005). https://doi.org/10.1038/sj.ijir.3901304

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