Original ArticleAssociation between MUC5B and TERT polymorphisms and different interstitial lung disease phenotypes
Section snippets
Ethics statement
Samples used in this study were collected with approval of institutional review boards of the Lung Tissue Research Consortium and the University of Chicago. Written informed consent was obtained from each participant. The Purdue University institutional review board has approved this study. The study was carried out in compliance with the Helsinki Declaration.
Study subjects
DNA extracted from peripheral blood of patients with ILD (n = 227) was obtained from the Lung Tissue Research Consortium. All patients
Demographic data and environmental covariates
We compared the distribution of demographic and environmental covariates data between each ILD subset and the normal lung control group. Significant differences were observed in the distribution of age, gender, and smoking status, but not BMI data. We also compared the difference in the data distribution between the IPF and non-IPF other ILD group. Only the distribution of age data was observed to be significantly different between these 2 groups (P = 0.01; Table I). These factors were then all
Discussion
Our study, for the first time, tested the associations between the TERT and MUC5B polymorphisms, and different sporadic ILD entities in a white population. Although the sample size is moderate, our findings confirmed that both polymorphisms confer susceptibility independently to ILD as an overall phenotype, with the MUC5B locus conveying a higher risk than the TERT polymorphism. Our results confirmed the findings that have been reported previously in genomewide studies.11, 12, 14, 15 However,
Acknowledgments
Conflicts of Interest: All authors have read the journal's policy on disclosure of potential conflicts of interest and have none to declare.
This study was supported in part by the National Institutes of Health/National Heart, Lung, and Blood Institute grant (R03 HL097016) (WL) and a startup fund (WL) by the Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University.
The authors thank the Lung Tissue Research Consortium (http://www.ltrcpublic.com) and the Translational
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