Original articleAssociation between Inadequate Sleep and Insulin Resistance in Obese Children
Section snippets
Methods
We reviewed the outpatient charts of 40 obese children (body mass index [BMI] > 95th percentile for age and sex) who had been followed in the Weight Management Center of the Section of Endocrinology and Diabetes at St Christopher’s Hospital for Children. Charts were included for review if patients were obese, had completed an oral glucose tolerance test (OGTT) and a fasting lipid panel, and, because of sleep-related complaints, had completed an overnight multichannel polysomnogram at the Sleep
Results
The charts of 40 obese children were reviewed (20 males; age range, 3.5 to 18.5 years; mean age, 12.3 years) (Table I). The mean total sleep duration measured was 373.4 ± 73 minutes. Fourteen subjects slept for < 6 hours. One subject slept for 15.5 minutes (parental termination of the sleep study); this subject’s data were not included in this analysis. When we divided our cohort into 2 groups according to sleep duration, we found higher fasting insulin (P = .02), peak insulin (P = .02), and
Discussion
Sleep loss is becoming increasingly prevalent in both adults and in children. The decline in sleep duration has paralleled a dramatic increase in the prevalence of obesity and diabetes. Recent data suggest that these two epidemics may have a mechanistic relationship. Our findings indicate a link between decreased sleep duration and increased insulin resistance in obese children. Children with short sleep duration have greater insulin resistance than children with normal sleep duration. In
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