Asthma and lower airway diseaseNeutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease
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Graphical abstract
Key words
Neutrophils
phagocytosis
chronic obstructive pulmonary disease
Haemophilus species
exacerbations
Abbreviations used
CAT
COPD Assessment Test
cfDNA
Cell-free DNA
COPD
Chronic obstructive pulmonary disease
EN-RAGE
Ligand for the receptor for advanced glycation end products
GOLD
Global Initiative for Obstructive Lung Disease
ICS
Inhaled corticosteroid
MPO
Myeloperoxidase
MRC
Medical Research Council
NET
Neutrophil extracellular trap
OTU
Operational taxonomic unit
PMA
Phorbol 12-myristate 13-acetate
SWDI
Shannon-Wiener species diversity index
Cited by (0)
Supported by the Chief Scientist Office, Scotland (grant no. ETM/262). J.D.C. acknowledges fellowship support from the Wellcome Trust. S.E.M. is an employee of the Wellcome Trust.
Disclosure of potential conflict of interest: O. Sibila has received grants from AstraZeneca and Menarini. J. S. Elborn has received a grant from Novartis. S. Schembri has received a grant from GlaxoSmithKline. C. N. A. Palmer has received a grant from AstraZeneca. J. D. Chalmers has received grants from AstraZeneca and Boehringer Ingelheim. The rest of the authors declare that they have no relevant conflicts of interest.
© 2017 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.