Mechanisms of asthma and allergic inflammationIL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life
Section snippets
Methods
The study was conducted in Sydney, Australia, a region where HDM is the dominant local allergen.13 Pregnant women whose unborn children were at high risk of developing asthma were recruited from the antenatal clinics in Sydney, Australia. Subjects (n = 616) were randomized to active and control arms for both HDM avoidance and the dietary intervention, separately, by using a factorial design. The trial objectives and design, including details of the participants, interventions, and environmental
Characteristics of the population
Valid data for 1 or more cytokine responses were available for 485 subjects, of whom 244 (50.3%) were male subjects and 242 (49.9%) had been randomly allocated to the active HDM avoidance group. There were 281 subjects with valid data for 1 or more cytokines at 18 months, 349 at 3 years, and 370 at 5 years (see this article's Table E1 in the Online Repository at www.jacionline.org). The proportion of subjects with positive SPTs to any allergen increased with age, and the proportion of these who
Discussion
House dust mite–specific IL-5 responses at ages 3 and 5 years were associated with allergic sensitization at 5 years, and IL-5 responses at 5 years were associated with asthma at that age. IL-5 responses were not related to the presence of eczema at this age. In contrast IL-13, IL-10, and IFN- γ responses to HDM were not independently related to asthma, eczema, or sensitization at age 5 years. HDM-specific IL-5, IL-13, and IL-10 increased over the first 5 years of life. HDM-specific IFN-γ
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2011, International ImmunopharmacologyCitation Excerpt :Glucocorticosteroid therapy has shown long term adverse effects, especially in children [11]. Specific allergen immunotherapy has its own limitations and cannot be applied to all the patients [32]. Plumbagin, which is being actively investigated in our laboratory for its immunosuppressive and anti-inflammatory activities in mice, [18,33] was explored for its potential anti-allergic and anti-inflammatory effects in human PBMC.
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Supported by National Health and Medical Research Council of Australia; the Cooperative Research Center for Asthma; the New South Wales Department of Health; the Children's Hospital Westmead; the Swiss National Science Foundation, PBZHB-114742 (C.W.-C.); the Swedish Heart Lung Foundation; and the Swedish Society of Medicine (C.A.). Contributions of goods and services were made by Allergopharma Joachim Ganzer KG Germany, John Sands Australia, Hasbro, Toll Refrigerated, AstraZeneca Australia, and Nu-Mega Ingredients Pty Ltd. Goods were provided at reduced cost by Auspharm, Allersearch, and Meadow Lea Foods.
Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.