Asthma diagnosis and treatmentSleep apnea is associated with bronchial inflammation and continuous positive airway pressure–induced airway hyperresponsiveness
Section snippets
Subjects
Fifty-seven consecutive patients (43 males and 14 females) with OSA were included in the study (Table I). OSA was confirmed by using nocturnal polysomnography. Patients were nonsmokers, and none had a previous OSA diagnosis or CPAP therapy. A control group of 13 healthy nonsmoking subjects was simultaneously analyzed. Atopy was investigated by using skin prick tests to a panel of 7 usual aeroallergens. Allergic sensitization was defined by the presence of at least 1 positive skin test (mean
Results
Anthropometric and clinical data are summarized in Table I. Groups were significantly different for body mass index and Epworth index (P < .001 and P < .05, respectively). The prevalences of atopy and allergic medical history were not different between OSA and control groups. In addition, no other inflammatory lung diseases (asthma, chronic bronchitis, systemic diseases) were reported by subjects from either group, and all subjects were nonsmokers. Overall, the subjects had normal pulmonary
Discussion
We demonstrated a neutrophilic bronchial inflammation in a large group of patients with OSA. The associated release of IL-8 in the supernatant of sputum induction was closely related with sleep apnea severity as expressed by the AHI and the amount of oxygen desaturation. This bronchial inflammation was not reversed by 1 month of CPAP use. In addition, we demonstrated for the first time that nasal CPAP induces a sustained increase in nonspecific airway responsiveness.
Severe asthma and COPD are
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2022, Sleep Medicine ReviewsCitation Excerpt :On the other hand, patients with asthma have shorter total sleep time, higher proportion of N2 and lower proportion of N3 sleep [17] as well as longer sleep latency [20]. Asthma diagnosis is primarily based on demonstrating the evidence of variability of airflow obstruction [1] but OSA itself is not associated with this [49,50]. Fractional exhaled nitric oxide (FeNO) is a surrogate breath biomarker for airway inflammation.
Use of Nasal Nitric Oxide in the Diagnosis of Allergic Rhinitis and Nonallergic Rhinitis in Patients with and without Sinus Inflammation
2020, Journal of Allergy and Clinical Immunology: In Practice
Supported by a grant from the French Committee of Respiratory Diseases (CNMR) and from the Fisher and Paykel Co.
Disclosure of potential conflict of interest: All of the authors have received grant support from the French Committee of Respiratory Diseases (Comité National Maladies Respiratoires) and Fisher and Paykel Co.