Clinical Research
Heart Rhythm Disorder
Pulmonary Vein Total Occlusion Following Catheter Ablation for Atrial Fibrillation: Clinical Implications After Long-Term Follow-Up

https://doi.org/10.1016/j.jacc.2006.08.038Get rights and content
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Objectives

We present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO).

Background

Pulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal.

Methods

Data from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]).

Results

The patients’ symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = −0.667, p < 0.05). A CSI ≥75% correlated well with low lung perfusion (<25%; r = −0.854, p < 0.01). Patients with a CSI ≥75% appeared to improve mostly when early (r = −0.497) and repeat dilation/stenting (r = 0.0765) were performed.

Conclusions

Patients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI ≥75% require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.

Abbreviations and Acronyms

AF
atrial fibrillation
CSI
cumulative stenosis index
CT
computed tomography
NYHA
New York Heart Association
PPI
percutaneous pulmonary intervention
PV
pulmonary vein
PVO
pulmonary vein occlusion
PVS
pulmonary vein stenosis
RFA
radiofrequency catheter ablation

Cited by (0)

1

Drs. Di Biase and Bai are trainees from the program “Second Level Master of Cardiac Electrophysiology and Pacing,” organized by University of Insubria, Varese, Italy.

2

Dr. Popova was supported by a grant from the Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.