Clinical lung and heart/lung transplantationThe 15-Step Oximetry Test: a Reliable Tool to Identify Candidates for Lung Transplantation Among Patients With Idiopathic Pulmonary Fibrosis
Section snippets
Patients and Setting
A prospective, open study design was used. The study group comprised 51 patients with IPF attending the Pulmonary Institute of Rabin Medical Center, a tertiary hospital in central Israel, during the 6-month period from January to June 2004. Diagnoses were made according to the criteria of the American Thoracic Society (ATS).1 Individuals with collagen vascular disease, occupational lung disease, sarcoid, hypersensitivity pneumonitis and/or other idiopathic interstitial pneumonias were excluded.
Demographic Data
All 51 patients completed the PFTs and the three exercise tests (CPET, 6MWD test and 15-step oximetry test).
Table 1 summarizes the demographic and clinical data. Twenty-nine patients were male. Mean age was 58 ± 11 years (range 17 to 80 years). Twenty-four patients were non-smokers, 25 had smoked in the past, and 2 continued to smoke during the study period. Most of the patients (94%) were New York Heart Association (NYHA) Functional Class II to IV. Twenty-five (50%) patients were being treated
Discussion
The main finding of the present study is that the lowest saturation on the simple step-climbing test is an accurate predictive parameter of mortality in IPF.
To provide patients with IPF with proper prognostic information, researchers have suggested various protocols with potential predictive value. It has been reported that increasing pulmonary artery pressure is a risk factor for death after single-lung transplantation in IPF.20 PFTs are traditionally used to evaluate patients with
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