ISHLT special report
Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part V: Predictors and Outcomes

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Short- and long-term outcomes of PGD

The recognition of outcomes of PGD is essential for determination of the impact of this early post-operative problem on short- and long-term prognosis. PGD remains responsible for significant early morbidity and mortality after lung transplantation.11 Relevant clinical outcomes of PGD include length of mechanical ventilation (LOV), ICU length of stay (LOS), hospital length of stay (hLOS), mortality, short- and long-term survival, cost, functional status and incidence of bronchiolitis obliterans

Predictors/scores of outcomes of PGD

Although there is more information on the prediction of development of PGD, there are limited data on the prediction of outcomes of PGD once it is present. Certain cellular, molecular, physiologic and clinical variables have been associated with outcomes in PGD in studies that typically included a small number of patients.

Fisher et al reported a significant association between high donor IL-8 concentration in bronchoalveolar lavage fluid and the development of early graft dysfunction and

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