Clinical lung and heart/lung transplantationEffect of Preoperative Pulmonary Artery Pressure on Early Survival After Lung Transplantation for Idiopathic Pulmonary Fibrosis
Section snippets
Design
The study was a retrospective cohort study that used the ISHLT registry database.
Patients
All adult patients who underwent lung transplantation from January 1, 1995, to June 30, 2002, with a diagnosis of IPF were eligible for inclusion. Patients with multiorgan transplants were excluded from the analysis because we thought that they would not be representative of the average IPF population undergoing lung transplantation. In addition, patients with unknown status at 90 days were also excluded from the
Results
From January 1, 1995, to June 30, 2002, a total of 1590 adult patients underwent lung transplantation for advanced lung disease due to IPF. Ninety-two patients were excluded because of unknown patient status at 90 days, and one was excluded because of multiorgan transplant. A total cohort of 1497 adult patients with IPF underwent lung transplantation and had 90-day follow-up reported. Of these, 667 patients did not have documented PA pressure data. This left a final cohort of 830 patients
Discussion
IPF accounts for approximately 20% of the advanced lung diseases that ultimately are treated with lung transplantation. The perioperative and long-term survival rates for patients with IPF are worse than the other most common indications for lung transplantation, emphysema and cystic fibrosis.10 The majority of long-term survival differences among these advanced lung diseases is because of significantly increased early posttransplant mortality in IPF. This group of patients may receive a
References (40)
- et al.
Effect of diagnosis on survival benefit of lung transplantation for end-stage lung disease
Lancet
(1998) - et al.
Assessment of survival benefit after lung transplantation by patient diagnosis
J Heart Lung Transplant
(2002) - et al.
Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis
J Thorac Cardiovasc Surg
(2003) - et al.
Listing for lung transplantationlife expectancy and transplant effect, stratified by type of end-stage lung disease, the eurotransplant experience
J Heart Lung Transplant
(2001) - et al.
The registry of the international society for heart and lung transplantationtwentieth official adult lung and heart-lung transplant report—2003
J Heart Lung Transplant
(2003) - et al.
Pulmonary artery systolic pressures estimated by echocardiogram vs cardiac catheterization in patients awaiting lung transplantation
J Heart Lung Transplant
(2001) - et al.
Impact of pulmonary hypertension on outcome after single-lung transplantation
Ann Thorac Surg
(1994) - et al.
Secondary pulmonary hypertension does not adversely affect outcome after single lung transplantation
J Thorac Cardiovasc Surg
(2000) - et al.
Morbidity, mortality, and early results of single versus bilateral lung transplantation for emphysema
J Thorac Cardiovasc Surg
(1992) - et al.
Single vs bilateral, sequential lung transplantation for end-stage emphysemainfluence of recipient age on survival and secondary end-points
J Heart Lung Transplant
(2001)