Chest
Original Research: Diffuse Lung DiseasePatients With Fibrotic Interstitial Lung Disease Hospitalized for Acute Respiratory Worsening: A Large Cohort Analysis
Section snippets
Definitions of Fibrotic Lung Disease and Patient Characteristics
Mayo Clinic Institutional Review Board approval was obtained (#12-010133). A search of the electronic medical records from January 1, 2000, to December 31, 2014, was performed for consecutive patients with suspected or known lung fibrosis and hospital admission for ARW using the search terms “lung fibrosis” and “acute respiratory failure.” Each admission was reassessed by study members for IPF diagnosis as defined by recent international criteria.12 Non-IPF cases were further categorized
Study Population
Two hundred and sixty-six patients were identified in the initial cohort, with 220 meeting inclusion criteria. These patients accounted for 311 unique ARW admissions. Population demographics are presented in Table 1. IPF accounted for 46% of presenting fibrotic lung disease followed by connective tissue disease-interstitial lung disease (CTD-ILD) (25%). Nearly one-third of patients (29%) presented without prior f-ILD diagnosis at the time of admission. Among previously diagnosed patients with
Discussion
Important findings from our study suggest that hospitalizations for ARW occur frequently in both patients with IPF and non-IPF fibrotic lung disease patients; in fact, patients without IPF accounted for the majority of consecutive patients with f-ILD admitted with ARW (54%) and 61% of all unique ARW admissions. Although a large-scale, single-center retrospective study, ours is the first to our knowledge to systematically review consecutive ARW admissions in a US-based population comparing f-ILD
Acknowledgments
Author contributions: All authors contributed to the conception, design, abstraction, and analysis of data, as well as writing of this manuscript. T.M. and K.G.L. are identified as guarantors of this manuscript.
Financial/nonfinancial disclosures: The authors have reported to CHEST the following: T.M. is the recipient of a Mayo Clinic intramural career development award, the Brewer Award for Research in Idiopathic Pulmonary Fibrosis, which partially funded research time to complete this
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2021, Respiratory InvestigationCitation Excerpt :Post-capillary PH has recently garnered considerable attention because previous studies have reported that this condition is associated with a decline in the quality of life, deterioration in exercise capacity, and poor survival in patients with left heart disease [3,12,13]. Previous studies have demonstrated that cardiac diseases are common in patients with ILD [14–17]. Raghu et al. showed that 4% of patients with idiopathic pulmonary fibrosis (IPF) had complicated post-capillary PH [18], but little is known about the prevalence of post-capillary PH in ILD.
FUNDING/SUPPORT: This study was funded in part by the Brewer Award for Research in Idiopathic Pulmonary Fibrosis.