ReviewLeptin, adiponectin and pulmonary diseases☆
Highlights
► Systemic leptin may be associated with greater asthma prevalence and severity in children. ► Systemic leptin may be associated with greater COPD prevalence and severity. ► Systemic adiponectin may be protective against odds for asthma among women and girls. ► Systemic adiponectin concentrations are higher in COPD patients than controls. ► Systemic adiponectin is associated with greater COPD severity in men.
Section snippets
COI disclosure
Nour Ali Assad, M.D. states that there is no personal or financial support or involvement with organization(s) with financial interest in the subject matter or any other actual or potential conflict of interest. Nour Ali Assad, M.D. also declares that she has materially participated in the article preparation including review of data, writing and editing of manuscript and creation of figures and has approved the final article.
Akshay Sood, M.D., M.P.H. states that there is no personal or
NIH source of funding
This work was supported from funding by the National Institutes of Health (K23 HL 094531-01 and CTSA 1ULRR031977-01 for AS). The sponsor played no role in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.
Acknowledgments
The authors would like to acknowledge the assistance provided by Mark Schuyler, M.D. at University of New Mexico in proof-reading and critiquing the article.
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Lipid mediators and asthma: Scope of therapeutics
2020, Biochemical PharmacologyCitation Excerpt :Its levels are increased in obese individual [66]. In contrast the levels of adiponectin, anti-inflammatory cytokine that inhibits pro-inflammatory factors (TNF-α, IL-6 and NF-κB) and stimulates IL-10 and IL-1 receptor antagonist are decreased in obese individuals [67]. Adiponectin is also known to have its receptor (AdipoR1) on airway epithelial cells and it inhibits the inflammatory pathways [68].
Adipokines in adolescence; the associations with lung function and atopy – A cross-sectional study
2020, Respiratory MedicineCitation Excerpt :Various hypotheses explaining these associations have been proposed, including alterations of airway anatomy or airway microbiome, genetics, insulin resistance and inflammation [7, 8]. Adipokines are inflammatory markers of fat metabolism and recently of interest as factors that may partly explain the link between obesity and subsequent asthma and reduced lung function [8-11]. Leptin is a proinflammatory adipokine mainly produced by adipose tissue, but also in human lung.
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Institution at which work was performed: University of New Mexico School of Medicine, Albuquerque, NM, USA