Original articleCardiovascularSuperior Vena Cava Resection for Lung and Mediastinal Malignancies: A Single-Center Experience With 70 Cases
Section snippets
Material and Methods
The primary objective of this study was to analyze the mortality, morbidity, and long-term results of SVC resection, both in terms of survival and in the patency of the prosthetic replacement, when performed. Our Ethical Committee was informed of the study and did not require approval. All patients gave their informed consent for the study.
Population
From November 1998 to May 2004, 70 patients underwent SVC system resection for either lung or mediastinal malignancies. Clinical characteristics of the population are reported in Table 2.
Fifty-two patients (42 male patients, median age 62,7 years) had SVC resection for nonsmall-cell lung cancer. Twenty-one patients (40%) underwent mediastinal investigation by mediastinoscopy before SVC surgery, and 40 (77%) received preoperative induction treatment (chemotherapy, n = 33; chemoradiation therapy,
Comment
Our series confirmed data from existing literature showing that resection of the SVC is a feasible additional procedure during resection of pulmonary or mediastinal tumors infiltrating the venous mediastinal axis, minimally increasing postoperative complications in experienced hands. Nevertheless, two questions regarding SVC surgery remain unaswered: what are the defining characteristics of an optimum candidate for SVC resection, and which SVC reconstruction technique provides the best results.
References (27)
- et al.
Superior vena cava reconstruction using autologous pericardium
Ann Thorac Surg
(1990) - et al.
Extended resection of the left atrium, great vessels, or both for lung cancer
Ann Thorac Surg
(1994) - et al.
Extended resections for bronchogenic carcionoma invading the superior vena cava system
Ann Thorac Surg
(2000) - et al.
Combined tracheal sleeve and superior vena cava resection for non small cell lung cancer
Ann Thorac Surg
(2000) - et al.
Results of superior vena cava resection for lung cancerAnalysis of prognostic factors
Lung Cancer
(2004) - et al.
15 Years single center experience with surgical resection of the superior vena cava for non-small cell lung cancer
Lung Cancer
(2004) - et al.
Long-term follow-up after prosthetic replacement of the superior vena cava combined with resection of mediastinal-pulmonary malignant tumors
J Thorac Cardiovasc Surg
(1991) - et al.
Long-term patency after replacement of the brachiocephalic veins combined with resection of mediastinal tumors
J Thorac Cardiovasc Surg
(2005) - et al.
Biological factors affecting long-term results of valvular heterografts
J Thorac Cardiovasc Surg
(1969) - et al.
Glutaraldehyde preserved autologous pericardium for patch reconstruction of the pulmonary artery and superior vena cava
Ann Thorac Surg
(2005)
Calcification of bovine pericardium: glutaraldheyde versus no-react biomodification
Ann Thorac Surg
Non small cell lung cancer
Extended operation for lung cancer invading the superior vena cava
Eur J Cardiothorac Surg
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