Original articleGeneral thoracicLung Cancer and Its Operable Brain Metastasis: Survival Rate and Staging Problems
Section snippets
Patients and Methods
In this multicenter (three thoracic surgery departments in Hungary) retrospective study, the data of 65 patients who underwent lung resection for primary lung cancer and brain metastasectomy for metastasis of the primary lung cancer between 1992–2001 were analyzed. The patients were divided into two groups depending on whether they exhibited synchronous or metachronous metastases. A metastasis was considered as synchronous if it appeared within 2 months of the detection of lung cancer.
Patients and Lung Cancer Related Symptoms
The mortality rate was 1.5% after lung resection (1 patient expired), and 6.1% after brain metastasectomy (4 patients expired). The overall mortality rate was 7.7% (5 out of 65 patients). Forty-four patients (67.7%) were symptom-free for lung cancer and only 21 patients (32.3%) experienced some symptoms that could be related to lung cancer. The stage distribution of lung cancer in patients with or without symptoms for lung cancer is indicated in Table 3. There were no significant differences
Comment
Similar to instances of lung metastasis from other organs [9], it was examined whether DFI is an important prognostic value after metastasectomy or not. Granone and associates indicated that their DFI ranged between 3–24 months [12] and there were no significant differences in survival rates between synchronous and metachronous patients. Burt and associates indicated that 60% of the distant metastases developed within patients 2 years after lung surgery [13]. Neoadjuvant treatment reduced the
References (17)
- et al.
The first site recurrence after complete resection in non-small-cell carcinoma of the lung
J Thorac Cardiovasc Surg
(1994) - et al.
Pathologic N1 non-small cell lung cancer: correlation between pattern of lymphatic spread and prognosis
J Thorac Cardiovasc Surg
(2003) Revisions in the International System for staging lung cancer
Chest
(1997)- et al.
Surgical management of non-small cell lung cancer with synchronous brain metastases
Chest
(2001) - et al.
And the Memorial Sloan-Kettering Cancer Center Thoracic StaffResection of brain metastases from non-small-cell lung carcinoma
J Thorac Cardiovasc Surg
(1992) - et al.
Intrapulmonary metastasis of non-small cell lung cancer: A prognostic assessment
J Thorac Cardiovasc Surg
(2001) - et al.
Stage III non-small cell lung cancer and metachronous brain metastases
J Thorac Cardiovasc Surg
(2002) - et al.
Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma
Cancer
(2002)
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2018, Lung CancerCitation Excerpt :However, aggressive local therapy may be appropriate for selected patients with limited-site oligometastatic disease and otherwise early-stage local disease [3–5]. Retrospective studies of small sample sizes, ranging from 12 to 144 patients, have shown reasonable long-term outcomes when pulmonary resection is utilized in patients who have single brain or adrenal metastases but an otherwise early-stage primary tumor, with 5-year survival of approximately 10–20% for patients with oligometastases disease to the brain [7,8,27–29] and 5-year survival of approximately 25% for patients with isolated metastasis to the adrenal gland [14,17]. As such, the NCCN guidelines consider surgical resection of the lung primary along with local treatment of the metastasis in combination with systemic chemotherapy to be an acceptable treatment in these patients.
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2017, Journal of Thoracic OncologyCitation Excerpt :Similarly, in a randomized study of 333 patients with one to three brain metastases (64% of patients with NSCLC), stereotactic radiosurgery (SRS) plus WBRT improved functional autonomy and OS for patients with a single unresectable brain metastasis when compared with WBRT alone.39 Retrospective case series of patients with NSCLC and isolated CNS disease have also shown that this subgroup of patients has a relatively good prognosis and may achieve long-term survival after LAT for the primary tumor and metastatic lesions.40,41,51 Taken together, these findings support the role of LAT in the treatment of intracranial oligometastatic disease.50