MiscellaneousRelation of Cardiac Complications in the Early Phase of Community-Acquired Pneumonia to Long-Term Mortality and Cardiovascular Events
Section snippets
Methods
The study was conducted at the University-Hospital Policlinico Umberto I (Rome, Italy). All patients admitted to medical wards with diagnosis of CAP through the emergency department from January 2011 to December 2014 were consecutively recruited and prospectively followed up. Patients who fulfilled the following criteria were enrolled in the study after giving written informed consent: (1) age ≥18 years; (2) clinical presentation of an acute illness with one or more of the following signs or
Results
We recruited 301 patients hospitalized for CAP (187 men and 114 women; age 71.8 ± 15.7 years). Most of the patients had arterial hypertension (70%). T2DM was present in 26%, chronic obstructive pulmonary disease in 34%, dyslipidemia in 24%, and a history of stroke in 12%. A history of paroxysmal atrial fibrillation was present in 14% of patients, whereas 12% were affected by chronic (persistent or permanent) atrial fibrillation and 13% had severe chronic kidney disease (i.e., a glomerular
Discussion
This study shows that cardiac complications occurring during the acute phase of hospitalization are associated with an enhanced risk of total mortality and CVEs in a follow-up of 2 years. Recent studies demonstrated that the early phase of pneumonia is complicated by cardiac events including acute coronary syndromes and arrhythmias, such as AF.4, 12, 13 Consistently with these reports, ∼20% of our population experienced MI and/or AF in the early phase of acute disease. Although the association
Disclosures
This work was supported by a grant from the Sapienza University of Rome, Rome, Italy (“Ricerche Universitarie” 2013, n. C26A13W5JX) to Prof. F. Violi. All the authors have no conflicts of interest to disclose.
References (19)
- et al.
Pneumonia, thrombosis and vascular disease
J Thromb Haemost
(2014) - et al.
Acute pneumonia and the cardiovascular system
Lancet
(2013) - et al.
Platelet activation is associated with myocardial infarction in patients with pneumonia
J Am Coll Cardiol
(2014) - et al.
The sum of two evils: pneumonia and myocardial infarction: is platelet activation the missing link?
J Am Coll Cardiol
(2014) - et al.
Role of acute infection in triggering acute coronary syndromes
Lancet Infect Dis
(2010) - et al.
Guideline-concordant therapy and reduced mortality and length of stay in adults with community-acquired pneumonia: playing by the rules
Arch Intern Med
(2009) - et al.
Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality
Circulation
(2012) - et al.
Outcomes of patients hospitalized with community-acquired, health care-associated, and hospital-acquired pneumonia
Ann Intern Med
(2009) - et al.
The Pneumonia Severity Index: a decade after the initial derivation and validation
Clin Infect Dis
(2008)
Cited by (102)
Low-grade endotoxemia is associated with cardiovascular events in community-acquired pneumonia
2024, Journal of InfectionRisk of atrial fibrillation in patients with pneumonia
2022, Heart and LungCitation Excerpt :Recent studies have reported that pneumonia often induces the development of cardiovascular diseases, such as heart failure, stroke, cardiac arrhythmias, and acute coronary syndrome (ACS).3–5 The development of cardiovascular complications is significantly associated with short-term mortality.6–9 Clinicians should be aware of such complications to improve outcomes in patients with pneumonia.
Coronavirus Disease-2019 (COVID-19) and Cardiovascular Complications
2021, Journal of Cardiothoracic and Vascular AnesthesiaExposome in ischaemic heart disease: Beyond traditional risk factors
2024, European Heart Journal
See page 650 for disclosure information.
- †
The full list of SIXTUS Study Group members is detailed in Appendix 1.