MiscellaneousNoninvasive Cardiac Output Measurement by Inert Gas Rebreathing in Suspected Pulmonary Hypertension
Section snippets
Methods
The present study involved 125 patients consecutively referred to our Pulmonary Hypertension Unit with an echocardiographic evaluation suggestive of PH. To confirm the diagnosis of PH, all subjects underwent right-sided cardiac catheterization, which included simultaneous CO determination by 3 techniques: thermodilution, direct Fick method, and IGR. Patients with severe chronic pulmonary disease at spirometry (forced expiratory volume <60% of predicted and vital capacity <60%), congenital heart
Results
From January 2008 to November 2012, 125 consecutive patients with an echocardiographic evaluation suggestive of PH were enrolled in the study. Thirty-seven patients had PH-NW, 68 had PH-HW, and 20 had normal pulmonary arterial pressure (Table 1). All patients underwent right-sided cardiac catheterization without complications. The hemodynamic features are detailed in Tables 2 and 3. In patients with PH, either with elevated or normal pulmonary wedge pressure, IGR overestimated CO (Table 3).
Discussion
The present study shows an overall agreement among CO determination by thermodilution, direct Fick method, and IGR in patients with PH without significant arterial hypoxemia. These results indicate that there is the possibility of a closer and better-tolerated hemodynamic follow-up in these patients. Indeed, although early treatment and combination therapies improved survival, PH remains a fatal disease.5 Many studies focused on finding accurate predictors of survival to develop an even more
Disclosures
The authors have no conflicts of interest to disclose.
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