MiscellaneousModerate Pulmonary Embolism Treated With Thrombolysis (from the “MOPETT” Trial)
Section snippets
Methods
The Moderate Pulmonary Embolism Treated with Thrombolysis trial was a prospective, controlled, randomized, single-center open study that enrolled 121 adult patients with symptomatic “moderate” PE. All patients provided written informed consent, and the institutional review board approved the study protocol.
Adult patients presenting with signs and symptoms suggestive of PE plus imaging documentation on computed tomographic angiography or ventilation/perfusion scanning were potentially eligible
Results
During a 22-month period from May 2008, 178 patients with PE were considered for enrollment in the present study. The patient flow is shown in Figure 2. Ultimately, 121 patients were randomized. The randomization process occurred after the inclusion and exclusion criteria were satisfied, and the patients had provided written informed consent. After evaluation of the patient, the study investigator placed a telephone call to the study center, and, by opening of sealed envelopes, randomization to
Discussion
The results have demonstrated that “safe dose” tPA is safe and effective in the treatment of moderate PE, leading to a significant early reduction in the pulmonary artery systolic pressure that was maintained through the intermediate term. This finding is consistent with the few published reports in this area. Only 4 reports have addressed the effects of pulmonary artery pressure changes after thrombolysis from a total of 257 patients10, 11, 12, 13 with PE. The largest of these was a
Disclosures
The authors have disclosed no conflicts of interest.
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