Elsevier

Advances in Immunology

Volume 77, 2001, Pages 263-295
Advances in Immunology

Mouse models of allergic airway disease

https://doi.org/10.1016/S0065-2776(01)77019-8Get rights and content

Publisher Summary

Animal models, including guinea pigs, monkeys, rats, and mice are used to study the pathogenesis of asthma. Mouse models of allergic lung disease are utilized to dissect the complex pathophysiological mechanisms underlying the asthma phenotype. The airways of patients with even mild asthma are inflamed, and some data suggest that the severity of asthma parallels the degree of this inflammation. The animal models are enabling to highlight specific pathways and to give the opportunity to study the function of these pathways in vivo. The challenge is to connect these pathways observed and identified in animal models to the equivalent in human airway disease. Moreover, models are of strategic importance in the testing and screening of novel therapeutic compounds. In the future, it is expected that as therapeutic agents are identified, in vitro disease models could be vital to understand how therapies work in vivo. It may be necessary to manipulate these models to potentiate particular pathways and parameters of human disease and test the efficacy of compounds in vivo.

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