Original articleHemostasis in cyanotic congenital heart disease**
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2012, Annals of Thoracic SurgeryCitation Excerpt :Although major causes of postoperative bleeding in pediatric cardiac surgery are thrombocytopenia, platelet dysfunction, and hemodilution, one possible cause is increased fibrinolysis during CPB [20, 21], which occurs in about 16% of patients [22]. Moreover, congenital heart disease itself in pediatric patients has been shown to be associated with fibrinolysis [22, 23]. We conducted a retrospective study to assess the benefit of TXA in pediatric cardiac surgery in a single-center population, with a good number of participants (231 patients) in relation to the literature, in which cyanotic (123) and acyanotic (108) patients were discretely balanced (1:13 ratio).
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Supported by Grant No. 425 from the Los Angeles and Riverside County Heart Associations, Medical Research Committee of Delta Delta Delta, and United States Public Health Service Grant No. FR-86 from the National Institutes of Health