Original article: general thoracicCharacteristics and prognosis of resected T3 non-small cell lung cancer
Section snippets
Patients and methods
From January 1984 to December 1996, 1,590 patients underwent pulmonary resection for NSCLC at Laennec Hospital and Boisguillaume Surgical Center. In all cases, the surgical procedure was a complete potentially curative resection with an extensive mediastinal lymph node dissection similar to that described by Martini and Flehinger [2]. All surgical specimens were studied by the same pathologist, who has reviewed all pathology notes for this study. Surgical pathologic distribution of T disease
Characteristics
Patient samples did not differ significantly among the three pT3 subgroups. Sex ratios were grossly the same and mean ages were 59.6 years, 60.2 years, and 61.9 years in the chest wall, bronchial, and mediastinal pT3 subgroups, respectively. Characteristics of the tumors are reported in Table 1. Lobectomies were more frequent among cases with chest wall pT3. Tumor size ranged from 0.2 cm to 19 cm in diameter (mean = 5.86 cm). The smallest tumors were found in the bronchial pT3 subgroup (p <
Comment
An extensive review of the English-language literature reveals that most of the articles studying pT3 NSCLC concern chest wall involvement only 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15. Some reports concern lung cancer invading the mediastinum but include T4 as well 16, 17, 18, 19. Only a few reports have focused on other subgroups than chest wall pT3 20, 21, 22. In addition, the pathologic characteristics of each subgroups are difficult to assess from the literature. This study was performed to
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2017, Clinical Lung CancerCitation Excerpt :The 5-year survival rate has been reported to range from 25% to 55%, with worse outcomes in patients with incomplete surgical resection and N2 nodal disease.8-13 The crude rates of local disease recurrence, generally defined as recurrence within the primary site or chest wall, have also varied widely in published reports from 1% to 17%.3,11,14-16 The role of adjuvant radiation therapy (RT) for patients with resected NSCLC with chest wall invasion remains controversial and largely undefined.
Prognostic Differences in Subgroups of Patients With Surgically Resected T3 Non-Small Cell Lung Cancer
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