International Journal of Immunopharmacology
Research paperThe effect of gliotoxin upon macrophage function
References (23)
- et al.
Glycogen synthase: the existence of a single demonstrable from in bovine adipose tissue
Archs Biochem. Biophys.
(1979) - et al.
Glycogen synthesis in resident and thioglycollate-elicited rat peritoneal exudate cells
Int. J. Biochem.
(1983) - et al.
Identification of an agent in cultures of Aspergillus fumigatus displaying antiphagocytic and immunomodulating activity in vitro
J. Gen. Microbiol.
(1985) - et al.
Rapid microassays for the measurement of superoxide and hydrogen peroxide modulation by monocytes in culture using an automatic enzyme immunoassay reader
J. Immun. Meth.
(1981) The use of lead citrate at high pH as an electron opaque stain in electron microscopy
J. Cell Biol.
(1963)- et al.
Experimental aspergillosis in normal rats infected intravenously
J. Reticuloendothel. Soc.
(1975) - et al.
Inhibition by sporidesmin of hepatic bile acid transport
Biochem. J.
(1983) Kinetics of killing of Listeria monocytogenes by macrophages: correlation of 3H-DNA release from labelled bacteria and changes in number of viable organisms by mathematical model
J. Reticuloendothel. Soc.
(1982)- et al.
Damage to hypal forms of fungi by human leukocytes
Am. J. Path.
(1978) - et al.
Agar accumulates in rat peritoneal macrophages elicited with thioglycollate broth
Scand. J. Immun.
(1983)
Hypothesis: fungal toxins are involved in aspergillosis and AIDS
Aust. J. exp. Biol. Med. Sci.
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2022, Physical Medicine and Rehabilitation Clinics of North AmericaCitation Excerpt :One such example is mycophenolic acid, under the brand name CellCept, which has been purified to prevent organ rejection in transplant recipients. Immunosuppression has been demonstrated in studies of other mycotoxins as well, including ochratoxin, trichothecenes, zearalenone, and gliotoxin.37,75–78 Aflatoxins are well-known for their toxic effects on the liver.
Fungal natural products galaxy: Biochemistry and molecular genetics toward blockbuster drugs discovery
2021, Advances in GeneticsCitation Excerpt :Different pathogenic fungi also biosynthesize the cytotoxic compounds belonging to NRPs class. Gliotoxin produced from Aspergillus fumigates and Trichoderma virens has immunosuppressive and cytotoxic effects on mammalian cells (Eichner, Al Salami, Wood, & Müllbacher, 1986; Scharf, Brakhage, & Mukherjee, 2016). Beauvericin is an example of NPs toxin produced by an entomopathogenic fungi Beauveria bassiana, which is used as an antibiotic and is insecticidal.
Natural roles of nonribosomal peptide metabolites in fungi
2020, MycoscienceMurine model of invasive pulmonary Aspergillosis: Follow-up of tissue injury, fungal burden and mortality with distinct elastase production strains
2019, Journal de Mycologie MedicaleCitation Excerpt :They include: gliotoxin [7,8], which is a potent inhibitor of the mucociliary system that compromises the expulsion of inhaled conidia and also inhibits the action of phagocytic cells and T lymphocytes; catalases [9,10], which are compounds that participate in the ablation of substances derived from the oxygen produced by macrophages and polymorphonuclear cells;
Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis
2012, Diagnostic Microbiology and Infectious DiseaseCitation Excerpt :Mass spectrometric analyses confirmed the identity of GT and bmGT in the CFs (data not shown). The presence of biologically active GT in CFs was confirmed by testing the toxicity of serial dilutions of CFs on L929 cells (Eichner etal., 1986). As shown in Figure S1A, CFs containing active GT (GT(+)) induced much higher levels of cell death of L929 cells than in those where no GT was detected (GT(−)).
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Present address: Anatomy and Pathology Department, Royal North Shore Hospital, St. Leonards, N.S.W. 2065, Australia.
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Present address: CSIRO, Division of Animal Health, Parkville, VIC 3062, Australia.