Original articleControlled clinical trial of 4 short-course regimens of chemotherapy (three 6-month and one 8-month) for pulmonary tuberculosis: Final report
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Pan-tuberculosis regimens: an argument against
2018, The Lancet Respiratory MedicinePyrazinamide pharmacokinetics and efficacy in adults and children
2012, TuberculosisCitation Excerpt :From the perspective of this review it should be noted that the dosage of PZA used in early studies was 2 g daily in a single dose for all patients.11,18 Other studies in East Africa and Asia gave a daily dosage of 2 g for patients weighing 50 kg or more and 1.5 g for those <50 kg19,20 Accepting the weight of pulmonary tuberculosis patients as ranging from 40 kg to 60 kg the dosage of PZA used would have ranged from 1.5 g for a 40 kg patient, or 37.5 mg/kg bodyweight, declining with increases in body weight to 31 mg/kg for a 49 kg patient, to 2 g for a 50 kg patient or 40 mg/kg with the dosage in mg/kg body weight again declining with every increase in body weight to 33 mg/kg for a 60 kg patient. In the study of Hong et al PZA dosages of 2 g for patients weighing ≥50 kg and 1.5 g for those <50 kg produced results that were not significantly different from those following the use of PZA dosages of >2 g/daily.21