Elsevier

Clinica Chimica Acta

Volume 142, Issue 3, 15 October 1984, Pages 307-311
Clinica Chimica Acta

Cholesterol fractions and triglycerides in children and adults with down's syndrome

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Abstract

In 186 patients with Down's syndrome (age 1–68 yr) total cholesterol and triglycerides were determined, quantitative lipoprotein electrophoresis was performed and cholesterol fractions and β/a-lipoprotein ratios were calculated. A reference group of 51 non-mongoloid mentally handicapped adults living in the same institutions were examined in the same way. Patients' total cholesterol, β-cholesterol and triglycerides did not differ from the controls. However, αcholesterol was significantly lower and the β/α-lipoprotein ratio significantly higher in patients, findings which are associated in the general population with a high risk for premature atherosclerosis. Interestingly, mortality causes and pathological findings in Down's syndrome show no increased frequency of cardiovascular diseases.

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