Case report
Pulmonary alveolar proteinosis in two siblings with decreased immunoglobulin A

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Abstract

A brother and sister with classic, biopsy proved pulmonary alveolar proteinosis are described. Both had low serum and low normal secretory immunoglobulin A (IgA) levels. A tendency for familial occurrence is possible and it is recommended that patients with pulmonary alveolar proteinosis, and their families, be evaluated for immunologic deficiencies.

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From the Departments of Medicine, Pathology and Anesthesia, Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, Illinois.

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